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Bioactive Compounds Isolated from Marine Bacterium Vibrio neocaledonicus and Their Enzyme Inhibitory Activities
Gomez-Betancur, Isabel; Zhao, Jianping2; Tan, Lin; Chen, Chang3; Yu, Ge; Rey-Suarez, Paola; Preciado, Lina1
2019
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume17Issue:7Pages:401
AbstractMarine organisms are recognized as a source of compounds with interesting biological activities. Vibrio neocaledonicus has been reported on for its high effectiveness against corrosion in metals but it has been little studied for its chemical and biological activities. In this study, four compounds were isolated from V. neocaledonicus: indole (1); 1H-indole-3-carboxaldehyde (2); 4-hydroxybenzaldehyde (3) and Cyclo (-Pro-Tyr) (4); using a bioassay-guided method, since in a previous study it was found that the ethyl acetate extract was active on the enzymes acetylcholinesterase (AChE), alpha-glucosidase (AG) and xanthine oxidase (XO). The inhibitory activities of the three compounds against AChE, AG and XO was also evaluated. In addition, the enzymatic inhibitory activity of indole to the toxins from the venom of Bothrops asper was tested. Results showed that indole exhibited strong inhibitory activity to AG (IC50 = 18.65 +/- 1.1 mu M), to AChE, and XO (51.3% and 44.3% at 50 mu g/mL, respectively). 1H-indole-3-carboxaldehyde displayed strong activity to XO (IC50 = 13.36 +/- 0.39 mu M). 4-hydroxybenzaldehyde showed moderate activity to XO (50.75% at 50 mu g/mL) and weak activity to AChE (25.7% at 50 mu g/mL). Furthermore, indole showed a significant in vitro inhibition to the coagulant effect induced by 1.0 mu g of venom. The findings were supported by molecular docking. This is the first comprehensive report on the chemistry of V. neocaledonicus and the bioactivity of its metabolites.
DepartmentLMB
KeywordVibrio neocaledonicus acetylcholinesterase (AChE) alphaglucosidase (AG) xanthine oxidase (XO) indole bioactive compounds snake venom
DOI10.3390/md17070401
Citation statistics
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17813
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.CATAS, Haikou Expt Stn, Haikou 571101, Hainan, Peoples R China
2.Univ Antioquia, Fac Ciencias Farmaceut & Alimentarias, Programa Ofidismo Escorpionismo, Medellin 1226, Colombia
3.Univ Mississippi, Sch Pharm, Natl Ctr Natl Prod Res, University, MS 38677 USA
4.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Gomez-Betancur, Isabel,Zhao, Jianping,Tan, Lin,et al. Bioactive Compounds Isolated from Marine Bacterium Vibrio neocaledonicus and Their Enzyme Inhibitory Activities[J]. MARINE DRUGS,2019,17(7):401.
APA Gomez-Betancur, Isabel.,Zhao, Jianping.,Tan, Lin.,Chen, Chang.,Yu, Ge.,...&Preciado, Lina.(2019).Bioactive Compounds Isolated from Marine Bacterium Vibrio neocaledonicus and Their Enzyme Inhibitory Activities.MARINE DRUGS,17(7),401.
MLA Gomez-Betancur, Isabel,et al."Bioactive Compounds Isolated from Marine Bacterium Vibrio neocaledonicus and Their Enzyme Inhibitory Activities".MARINE DRUGS 17.7(2019):401.
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