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New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015
Pang, Xiaoyan1,2; Cai, Guodi3; Lin, Xiuping1; Salendra, Limbadri1; Zhou, Xuefeng1; Yang, Bin1; Wang, Junjian3; Wang, Junfeng1; Xu, Shihai; Liu, Yonghong1
2019
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume17Issue:7Pages:398
AbstractThe sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1-21), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR-ESI-MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC50 value of 5.19 mu M. Compounds 9 and 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii, respectively, both with MIC values of 57 mu g/mL. Furthermore, compound 16 displayed potent antibacterial activity against S. aureus with an MIC value of 3.75 mu g/mL.
DepartmentLMB
Keywordsponge-derived fungus Penicillium sp alkaloid X-ray single crystal diffraction antibacterial cytotoxic activity
DOI10.3390/md17070398
Citation statistics
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17814
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Jinan Univ, Coll Chem & Mat Sci, Guangzhou 510632, Guangdong, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Materia Med, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
3.Jinan Univ, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
4.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Pang, Xiaoyan,Cai, Guodi,Lin, Xiuping,et al. New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015[J]. MARINE DRUGS,2019,17(7):398.
APA Pang, Xiaoyan.,Cai, Guodi.,Lin, Xiuping.,Salendra, Limbadri.,Zhou, Xuefeng.,...&Liu, Yonghong.(2019).New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015.MARINE DRUGS,17(7),398.
MLA Pang, Xiaoyan,et al."New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015".MARINE DRUGS 17.7(2019):398.
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