SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
Uptake, Elimination, and Biotransformation Potential of a Progestagen (Cyproterone Acetate) in Tilapia Exposed at an Environmental Concentration
Liu, Shan; Su, Haochang2; Li, Heng-Xiang; Liu, Jin-Jun; Lin, Lang3; Xu, Xiang-Rong; Zuo, Lin-Zi; Zhao, Jian-Liang
2019
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume53Issue:12Pages:6804
AbstractAlthough the distribution of progestagens in aquatic environments has been widely reported, details on their uptake, elimination, and biotransformation in fish have received little attention. This study investigated the uptake, elimination, and biotransformation potential of a progestagen, cyproterone acetate (CPTA), in Nile tilapia (Oreochromis niloticus) exposed to an environmentally relevant concentration under semistatic regimes. CPTA in tilapia tissues followed a similar pattern, reaching a concentration plateau within 4 days of exposure, and dropping to below limits of quantitation within 4 days of elimination. The calculated steady-state bioconcentration factors suggest a low bioconcentration potential of CPTA in juvenile tilapia. Results of enzymatic hydrolysis treatments revealed that no conjugates of CPTA were present in tissues, but conjugated biotransformation products of CPTA were found in bile, liver, and muscle. Most CPTA entered tissues and then was biotransformed into seven different products by phase I and phase II metabolism. The concentrations of endogenous cortisol were significantly influenced by CPTA in plasma and liver during the uptake period. These findings suggest that biotransformation products of CPTA should be considered for the assessment of the bioconcentration potential and ecological effects of progestagens.
DepartmentLMB
DOI10.1021/acs.est.9b02891
Citation statistics
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17824
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Prov Key Lab Appl Marine Biol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China
2.South China Normal Univ, MOE Key Lab Theoret Chem Environm, Environm Res Inst, Guangzhou 510006, Guangdong, Peoples R China
3.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Minist Agr & Rural Affairs, Key Lab South China Sea Fishery Resources Exploit, Guangzhou 510300, Guangdong, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Liu, Shan,Su, Haochang,Li, Heng-Xiang,et al. Uptake, Elimination, and Biotransformation Potential of a Progestagen (Cyproterone Acetate) in Tilapia Exposed at an Environmental Concentration[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2019,53(12):6804, 6813.
APA Liu, Shan.,Su, Haochang.,Li, Heng-Xiang.,Liu, Jin-Jun.,Lin, Lang.,...&Zhao, Jian-Liang.(2019).Uptake, Elimination, and Biotransformation Potential of a Progestagen (Cyproterone Acetate) in Tilapia Exposed at an Environmental Concentration.ENVIRONMENTAL SCIENCE & TECHNOLOGY,53(12),6804.
MLA Liu, Shan,et al."Uptake, Elimination, and Biotransformation Potential of a Progestagen (Cyproterone Acetate) in Tilapia Exposed at an Environmental Concentration".ENVIRONMENTAL SCIENCE & TECHNOLOGY 53.12(2019):6804.
Files in This Item:
File Name/Size DocType Version Access License
Uptake, Elimination,(1754KB)期刊论文出版稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.