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New pyrone and cyclopentenone derivatives from marine-derived fungus Aspergillus sydowii SCSIO 00305
Amin, Muhammad1; Liang, Xiao1; Ma, Xuan; Dong, Jun-De; Qi, Shu-Hua
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
AbstractTwo new 2-pyrone derivatives sydowiones A-B (1, 2), one new cyclopentenone derivative sydowione C (3), and one new mycotoxin 6-methoxyl austocystin A (4) along with two known analogues paecilpyrone A (5) and austocystin A (6), were isolated from the marine-derived fungus Aspergillus sydowii SCSIO 00305. The structures of 1-4 were elucidated by extensive spectroscopic analysis. The absolute configuration of C-8 in 1 was established by Mosher method, and further confirmed by calculation of the electronic circular dichroism (ECD) spectra. The absolute configuration of C-11 in 3 was also determined by calculation of ECD spectra. The absolute configuration of 6 was determined by a single-crystal X-ray diffraction experiment for the first time. Compounds 1-4 showed moderate toxicity towards brine shrine naupalii with LC50 values of 19.5, 14.3, 8.3 and 2.9 mu M, respectively. And 1 and 2 also showed antioxidant activity against 2,2-diphenyl-picrylhydrazyl (DPPH) radicals with IC50 values of 46.0 and 46.6 mu M, respectively. [GRAPHICS] .
DepartmentLMB
KeywordAspergillus sydowii 2-pyrone derivative cyclopentenone derivative mycotoxin toxicity
DOI10.1080/14786419.2019.1629919
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Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17825
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Inst South China Sea Ecol & Environm Engn, Guangdong Key Lab Marine Mat Med,South China Sea, Guangzhou, Guangdong, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Amin, Muhammad,Liang, Xiao,Ma, Xuan,et al. New pyrone and cyclopentenone derivatives from marine-derived fungus Aspergillus sydowii SCSIO 00305[J]. NATURAL PRODUCT RESEARCH.
APA Amin, Muhammad,Liang, Xiao,Ma, Xuan,Dong, Jun-De,&Qi, Shu-Hua.
MLA Amin, Muhammad,et al."New pyrone and cyclopentenone derivatives from marine-derived fungus Aspergillus sydowii SCSIO 00305".NATURAL PRODUCT RESEARCH
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