SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor alpha
Liang, Xiao1; Zhang, Xuelian2; Lu, Xinhua2; Zheng, Zhihui2; Ma, Xuan; Qi, Shuhua
2019
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume82Issue:6Pages:1558
AbstractEight new diketopiperazine-type alkaloids including four oxepin-containing diketopiperazine-type alkaloids, oxepinamides H-K (1-4), and four 4-quinazolinone alkaloids, puniceloids A-D (5-8), together with two known analogues (9 and 10), were isolated from the culture broth extracts of the deep-sea-derived fungus Aspergillus puniceus SCSIO z021. Their structures were elucidated by spectroscopic analyses, and their absolute configurations were determined by Marfey's method along with comparison of their specific rotations and ECD spectra. The absolute configurations of 4 and 5 were further confirmed by a single-crystal X-ray diffraction analysis. Compounds 1-8 showed significant transcriptional activation of liver X receptor alpha with EC50 values of 1.7-50 mu M, and 7 and 8 were the most potent agonists.
DepartmentLMB
DOI10.1021/acs.jnatprod.9b00055
Citation statistics
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17832
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, South China Sea Inst Oceanol, Inst South China Sea Ecol & Environm Engn, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.North China Pharmaceut Grp Corp, New Drug Res & Dev Co Ltd, Shijiazhuang 050015, Hebei, Peoples R China
Recommended Citation
GB/T 7714
Liang, Xiao,Zhang, Xuelian,Lu, Xinhua,et al. Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor alpha[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(6):1558, 1564.
APA Liang, Xiao,Zhang, Xuelian,Lu, Xinhua,Zheng, Zhihui,Ma, Xuan,&Qi, Shuhua.(2019).Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor alpha.JOURNAL OF NATURAL PRODUCTS,82(6),1558.
MLA Liang, Xiao,et al."Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor alpha".JOURNAL OF NATURAL PRODUCTS 82.6(2019):1558.
Files in This Item:
File Name/Size DocType Version Access License
Diketopiperazine-Typ(1488KB)期刊论文出版稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.