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Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSI041301
Liu, Nianzhen1; Peng, Shuai1; Yang, Jie2; Cong, Ziwen; Lin, Xiuping; Liao, Shengrong; Yang, Bin; Zhou, Xuefeng; Zhou, Xiaojiang1; Liu, Yonghong3; Wang, Junfeng
2019
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume135Pages:27
AbstractFive new compounds, including one bisabolane-type sesquiterpenoids, namely aspergillusene D (1), two new xanthones (2 and 3), and two new catecholderivatives (4 and 5), together with fourteen known compounds (6-19), were isolated and identified from the fungus Aspergillus sydowiiSCSIO 41,301 from the sponge Phakellia fusca. Their structures and absolute configurations were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Most of the isolated compounds (1-3, and 6-19) were evaluated for their antiviral, cytotoxic, and antibacterial activities. Among them, new compounds 2 and 3 displayed obvious selective inhibitory activities against two influenza A virus subtypes, including A/Puerto Rico/8/34 (H1N1) and A/FM-1/1/47 (H1N1), with IC50 values ranging from 2.17 +/- 1.39 to 4.70 +/- 1.11 mu M.
DepartmentLMB
KeywordAspergillus sydowii Sesquiterpenoid Xanthone Antiviral activity
DOI10.1016/j.fitote.2019.03.031
Citation statistics
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17836
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China
2.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China
3.Southern Med Univ, Guangdong Prov Key Lab New Drug Screening, Guangzhou Key Lab Drug Res Emerging VirusPrevent, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Liu, Nianzhen,Peng, Shuai,Yang, Jie,et al. Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSI041301[J]. FITOTERAPIA,2019,135:27, 32.
APA Liu, Nianzhen.,Peng, Shuai.,Yang, Jie.,Cong, Ziwen.,Lin, Xiuping.,...&Wang, Junfeng.(2019).Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSI041301.FITOTERAPIA,135,27.
MLA Liu, Nianzhen,et al."Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSI041301".FITOTERAPIA 135(2019):27.
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