Knowledge Management System Of South China Sea Institute of Oceanology,CAS
| Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSI041301 | |
| Liu, Nianzhen1; Peng, Shuai1; Yang, Jie2; Cong, Ziwen; Lin, Xiuping; Liao, Shengrong; Yang, Bin; Zhou, Xuefeng; Zhou, Xiaojiang1; Liu, Yonghong3; Wang, Junfeng | |
| 2019 | |
| Source Publication | FITOTERAPIA
 |
| ISSN | 0367-326X |
| Volume | 135Pages:27 |
| Abstract | Five new compounds, including one bisabolane-type sesquiterpenoids, namely aspergillusene D (1), two new xanthones (2 and 3), and two new catecholderivatives (4 and 5), together with fourteen known compounds (6-19), were isolated and identified from the fungus Aspergillus sydowiiSCSIO 41,301 from the sponge Phakellia fusca. Their structures and absolute configurations were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Most of the isolated compounds (1-3, and 6-19) were evaluated for their antiviral, cytotoxic, and antibacterial activities. Among them, new compounds 2 and 3 displayed obvious selective inhibitory activities against two influenza A virus subtypes, including A/Puerto Rico/8/34 (H1N1) and A/FM-1/1/47 (H1N1), with IC50 values ranging from 2.17 +/- 1.39 to 4.70 +/- 1.11 mu M. |
| Department | LMB |
| Keyword | Aspergillus sydowii Sesquiterpenoid Xanthone Antiviral activity |
| DOI | 10.1016/j.fitote.2019.03.031 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.scsio.ac.cn/handle/344004/17836 |
| Collection | 中科院海洋生物资源可持续利用重点实验室 |
| Affiliation | 1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China 2.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China 3.Southern Med Univ, Guangdong Prov Key Lab New Drug Screening, Guangzhou Key Lab Drug Res Emerging VirusPrevent, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Nianzhen,Peng, Shuai,Yang, Jie,et al. Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSI041301[J]. FITOTERAPIA,2019,135:27, 32. |
| APA | Liu, Nianzhen.,Peng, Shuai.,Yang, Jie.,Cong, Ziwen.,Lin, Xiuping.,...&Wang, Junfeng.(2019).Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSI041301.FITOTERAPIA,135,27. |
| MLA | Liu, Nianzhen,et al."Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSI041301".FITOTERAPIA 135(2019):27. |
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| Structurally diverse（786KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | Application Full Text | |
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