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Cytotoxicity of polyketides and steroids isolated from the sponge-associated fungus Penicillium citrinum SCSIO 41017
Salendra, Limbadri1; Lin, Xiuping; Chen, Weihao1; Pang, Xiaoyan2; Luo, Xiaowei1; Long, Jieyi1; Liao, Shengrong; Wang, Junfeng; Zhou, Xuefeng; Liu, Yonghong1,3; Yang, Bin
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
AbstractTwo new polyketides, xerucitrinin A (1) and coniochaetone M (8), and one new steroid, 16 alpha-methylpregna-17 alpha,19-dihydroxy-(9,11)-epoxy-4-ene-3,18-dione-20-acetoxy (13), together with eleven known analogues were isolated from fungus Penicillium citrinum SCSIO 41017 associated with the sponge Callyspongia sp. Their structures and absolute configurations were elucidated by NMR spectra, MS, CD, optical rotation, X-ray crystallography, and compared with literature data. Biological evaluation results revealed that 5 exhibited significant cytotoxic activity against MCF-7 cell line with IC50 values of 1.3 mu M. Compound 13 showed moderate activity against all cell lines with IC50 values of 13.5-18.0 mu M, and compounds 9 and 14 showed weak activity with MIC values of ranging from 125 mu g/mL to 250 mu g/mL respectively. [GRAPHICS] .
DepartmentLMB
KeywordSponge-associated fungus Penicillium citrinum SCSIO 41017 polyketides steroids cytotoxicity
DOI10.1080/14786419.2019.1610757
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17837
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol,Res Ctr Marine Micro, Guangzhou 510301, Guangdong, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Jinan Univ, Coll Chem & Mat Sci, Dept Chem, Guangzhou, Guangdong, Peoples R China
4.Chinese Acad Sci, Inst South China Sea Ecol & Environm Engn, Guangzhou 510301, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Salendra, Limbadri,Lin, Xiuping,Chen, Weihao,et al. Cytotoxicity of polyketides and steroids isolated from the sponge-associated fungus Penicillium citrinum SCSIO 41017[J]. NATURAL PRODUCT RESEARCH.
APA Salendra, Limbadri.,Lin, Xiuping.,Chen, Weihao.,Pang, Xiaoyan.,Luo, Xiaowei.,...&Yang, Bin.
MLA Salendra, Limbadri,et al."Cytotoxicity of polyketides and steroids isolated from the sponge-associated fungus Penicillium citrinum SCSIO 41017".NATURAL PRODUCT RESEARCH
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