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Syn-2, 3-diols and anti-inflammatory indole derivatives from Streptomyces sp. CB09001
Jiang, Lin; Pu, Hong2; Qin, Xiangjing1; Liu, Jianxin2; Wen, Zhongqing; Huang, Yimin2; Xiang, Jingxi; Xiang, Yunxi2; Ju, Jianhua1; Duan, Yanwen3,4; Huang, Yong4
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
AbstractTwo new natural diols, (2S, 3S, 4S)-4-methyl-1-phenylhexane-2,3-diol (1) and (2S, 3S)-4-methyl-1-phenylpentane-2,3-diol (2), together with five known compounds, xenocyloins B-D (3-5), lumichrome (6) and thymidine (7) were isolated from Streptomyces sp. CB09001. The absolute configurations of 1 and 2 were established by crystallographic structure analysis. The anti-inflammatory effects of 1-7 were also investigated in RAW246.7 murine macrophage cells stimulated by lipopolysaccharide. The indole derivative xenocyloin B (3) significantly inhibited inducible nitric oxide synthase expression in RAW264.7 cells and could be a potential anti-inflammatory drug lead.
DepartmentLMB
DOI10.1080/14786419.2019.1611812
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Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17839
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Cent S Univ, Xiangya Int Acad Translat Med, Changsha 410013, Hunan, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Materia Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou, Guangdong, Peoples R China
3.Hunan Univ Med, Sch Pharmaceut Sci, Huaihua, Hunan, Peoples R China
4.Hunan Engn Res Ctr Combinatorial Biosynth & Nat P, Changsha 410011, Hunan, Peoples R China
5.Natl Engn Res Ctr Combinatorial Biosynth Drug Dis, Changsha 410011, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Lin,Pu, Hong,Qin, Xiangjing,et al. Syn-2, 3-diols and anti-inflammatory indole derivatives from Streptomyces sp. CB09001[J]. NATURAL PRODUCT RESEARCH.
APA Jiang, Lin.,Pu, Hong.,Qin, Xiangjing.,Liu, Jianxin.,Wen, Zhongqing.,...&Huang, Yong.
MLA Jiang, Lin,et al."Syn-2, 3-diols and anti-inflammatory indole derivatives from Streptomyces sp. CB09001".NATURAL PRODUCT RESEARCH
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