SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent
Tan, Suiyi; Yang, Bin1; Liu, Juan1; Xun, Tianrong; Liu, Yonghong1; Zhou, Xuefeng1
2019
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
Volume33Issue:10Pages:1467
AbstractMarine micro-organisms have been proven to be excellent sources of bioactive compounds against HIV-1. Several natural products obtained from marine-derived Aspergillus fungi were screened for their activities to inhibit HIV-1 infection. Penicillixanthone A (PXA), a natural xanthone dimer from jellyfish-derived fungus Aspergillus fumigates, displayed potent anti-HIV-1 activity by inhibiting infection against CCR5-tropic HIV-1 SF162 and CXCR4-tropic HIV-1 NL4-3, with IC50 of 0.36 and 0.26 mu M, respectively. Molecular docking study was conducted to understand the possible binding mode of PXA with the CCR5/CXCR4. The results revealed that, the marine-derived PXA, as a CCR5/CXCR4 dual-coreceptor antagonist, presents a new type of potential lead product for the development of anti-HIV therapeutics.
DepartmentLMB
KeywordPenicillixanthone A anti-HIV-1 CCR5 CXCR4 marine fungi
DOI10.1080/14786419.2017.1416376
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Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17845
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.South Med Univ, Guangzhou Key Lab Drug Res Emerging Virus Prevent, Guangdong Prov Key Lab New Drug Screening, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China
2.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, Key Lab Trop Marine Bioresources & Ecol, Guangzhou, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Tan, Suiyi,Yang, Bin,Liu, Juan,et al. Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent[J]. NATURAL PRODUCT RESEARCH,2019,33(10):1467, 1471.
APA Tan, Suiyi,Yang, Bin,Liu, Juan,Xun, Tianrong,Liu, Yonghong,&Zhou, Xuefeng.(2019).Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent.NATURAL PRODUCT RESEARCH,33(10),1467.
MLA Tan, Suiyi,et al."Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent".NATURAL PRODUCT RESEARCH 33.10(2019):1467.
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