SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster
Huang, Chunshuai1; Yang, Chunfang; Zhang, Wenjun; Zhu, Yiguang; Ma, Liang; Fang, Zhuangjie1; Zhang, Changsheng1
2019
Source PublicationJOURNAL OF ANTIBIOTICS
ISSN0021-8820
Volume72Issue:5Pages:311
AbstractHeterologous expression of the fluostatin biosynthetic gene cluster from the marine-derived Micromonospora rosaria SCSIO N160 in Streptomyces albus J1074 led to the isolation of a novel isoindolequinone albumycin (1) and a known isoquinolinequinone mansouramycin A (2). The structure of 1 was elucidated on the basis of detailed 1D and 2D NMR spectroscopic analysis. Mansouramycin A (2) is active against methicillin-resistant Staphylococcus aureus ATCC 43300, with a MIC of 8 mu g ml(-1), while albumycin (1) displayed negligible antibacterial activities. This study represents another example of activation of secondary metabolites that are non-relevant to the heterologously introduced biosynthetic gene cluster in a bacterial host.
DepartmentLMB
DOI10.1038/s41429-019-0161-4
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17855
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,South China Sea, RNAM Ctr Marine Microbiol,Inst South China Sea Ec, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Huang, Chunshuai,Yang, Chunfang,Zhang, Wenjun,et al. Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster[J]. JOURNAL OF ANTIBIOTICS,2019,72(5):311, 315.
APA Huang, Chunshuai.,Yang, Chunfang.,Zhang, Wenjun.,Zhu, Yiguang.,Ma, Liang.,...&Zhang, Changsheng.(2019).Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster.JOURNAL OF ANTIBIOTICS,72(5),311.
MLA Huang, Chunshuai,et al."Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster".JOURNAL OF ANTIBIOTICS 72.5(2019):311.
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