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Discovery and Biosynthesis of Atrovimycin, an Antitubercular and Antifungal Cyclodepsipeptide Featuring Vicinal-dihydroxylated Cinnamic Acyl Chain
Liu, Qing1,2; Liu, Zhiyong3; Sun, Changli2; Shao, Mingwei2; Ma, Junying2; Wei, Xiaoyi4; Zhang, Tianyu3,5; Li, Wenjun1; Ju, Jianhua2,5
2019
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume21Issue:8Pages:2634
AbstractAtrovimycin (1), a cyclodepsipeptide containing a unique vicinal-hydroxylated cinnamic acyl chain, was isolated and elucidated from Streptomyces atrovirens LQ13. The biosynthetic pathway of 1 was achieved, revealing cytochrome P450 (Avm43) and epoxide hydrolase (Avm29) enzymes constructing the vicinal-dihydroxy substitution, as well as a tailoring P450 (Avm28) enzyme catalyzing beta-hydroxylation of the L-Phe moiety. Atrovimycin shows in vitro antifungal activity and antitubercular activity against Mycobacterium tuberculosis H37Rv both in vitro (with MIC of 2.5 mu g/mL) and in vivo.
DepartmentLMB
DOI10.1021/acs.orglett.9b00618
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17860
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Sch Life Sci, Guangdong Prov Key Lab Plant Resources, Guangzhou 510275, Guangdong, Peoples R China
3.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou 510301, Guangdong, Peoples R China
4.Chinese Acad Sci, GIBH, Guangzhou Regenerat Med & Hlth Guangdong Lab GRMH, State Key Lab Resp Dis, Guangzhou 510530, Guangdong, Peoples R China
5.Chinese Acad Sci, South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China
6.Univ Chinese Acad Sci, Beijing 110039, Peoples R China
Recommended Citation
GB/T 7714
Liu, Qing,Liu, Zhiyong,Sun, Changli,et al. Discovery and Biosynthesis of Atrovimycin, an Antitubercular and Antifungal Cyclodepsipeptide Featuring Vicinal-dihydroxylated Cinnamic Acyl Chain[J]. ORGANIC LETTERS,2019,21(8):2634, 2638.
APA Liu, Qing.,Liu, Zhiyong.,Sun, Changli.,Shao, Mingwei.,Ma, Junying.,...&Ju, Jianhua.(2019).Discovery and Biosynthesis of Atrovimycin, an Antitubercular and Antifungal Cyclodepsipeptide Featuring Vicinal-dihydroxylated Cinnamic Acyl Chain.ORGANIC LETTERS,21(8),2634.
MLA Liu, Qing,et al."Discovery and Biosynthesis of Atrovimycin, an Antitubercular and Antifungal Cyclodepsipeptide Featuring Vicinal-dihydroxylated Cinnamic Acyl Chain".ORGANIC LETTERS 21.8(2019):2634.
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