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Phages Mediate Bacterial Self-Recognition
Song, Sooyeon; Guo, Yunxue1; Kim, Jun-Seob; Wang, Xiaoxue1; Wood, Thomas K.
2019
Source PublicationCELL REPORTS
ISSN2211-1247
Volume27Issue:3Pages:737
AbstractCells are social, and self-recognition is a conserved aspect of group behavior where cells assist kin and antagonize non-kin. However, the role of phage in self-recognition is unexplored. Here we find that a demarcation line is formed between different swimming Escherichia coli strains but not between identical clones; hence, motile cells discriminate between self and non-self. The basis for this self-recognition is a 49 kb, T1-type, lytic phage of the family Siphoviridae (named here SW1) that controls formation of the demarcation line by utilizing one of the host's cryptic prophage proteins, YfdM of CPS-53, to propagate. Critically, SW1 provides a conditional benefit to E. coli K-12 compared with the identical strain that lacks the phage. A demarcation line is also formed when strains harbor either the lysogenic phage phi 80 or lambda and encounter siblings that lack the lysogen. In summary, bacteria can use phage to distinguish siblings that lack phage.
DepartmentLMB
DOI10.1016/j.celrep.2019.03.070
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17861
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.[Song, Sooyeon; Wood, Thomas K.] Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA
2.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China
3.Korea Res Inst Biosci & Biotechnol, Infect Dis Res Ctr, Daejeon 34141, South Korea
Recommended Citation
GB/T 7714
Song, Sooyeon,Guo, Yunxue,Kim, Jun-Seob,et al. Phages Mediate Bacterial Self-Recognition[J]. CELL REPORTS,2019,27(3):737, +.
APA Song, Sooyeon,Guo, Yunxue,Kim, Jun-Seob,Wang, Xiaoxue,&Wood, Thomas K..(2019).Phages Mediate Bacterial Self-Recognition.CELL REPORTS,27(3),737.
MLA Song, Sooyeon,et al."Phages Mediate Bacterial Self-Recognition".CELL REPORTS 27.3(2019):737.
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