SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster
Sun, Changli; Yang, Zhijie2; Zhang, Chunyan2; Liu, Zhiyong1; He, Jianqiao2; Liu, Qing3,4; Zhang, Tianyu1,2; Ju, Jianhua2; Ma, Junying
2019
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume21Issue:5Pages:1453
AbstractGenome mining of the deep sea-derived Streptomyces atratus SCSIO ZH16 enabled the activation of a cyclodepsipeptide gene cluster and isolation of its cinnamic acid-bearing product, atratumycin (1). Atratumycin's structure was elucidated on the basis of extensive spectroscopic experiments, X-ray data, and Marfey's method; a plausible biosynthesis and tailoring modification of 1 are also proposed and investigated. Additionally, atratumycin is active against Mycobacteria tuberculosis H37Ra and H37Rv with MICs of 3.8 and 14.6 mu M, respectively.
DepartmentLMB
DOI10.1021/acs.orglett.9b00208
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17884
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou 510301, Guangdong, Peoples R China
2.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, State Key Lab Resp Dis, TB Res Lab, Guangzhou 510530, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
4.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China
5.Sun Yat Sen Univ, Sch Life Sci, Guangdong Prov Key Lab Plant Resources, Guangzhou 510275, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Sun, Changli,Yang, Zhijie,Zhang, Chunyan,et al. Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster[J]. ORGANIC LETTERS,2019,21(5):1453, 1457.
APA Sun, Changli.,Yang, Zhijie.,Zhang, Chunyan.,Liu, Zhiyong.,He, Jianqiao.,...&Ma, Junying.(2019).Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster.ORGANIC LETTERS,21(5),1453.
MLA Sun, Changli,et al."Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster".ORGANIC LETTERS 21.5(2019):1453.
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