SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field
Lin, Xiuping; Li, Kunlong1; Yang, Lilin3; Peng, Xiaoying4; Fang, Wei2; Tian, Xinpeng; Liu, Yonghong; Zhou, Xuefeng
2019
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
Volume33Issue:4Pages:494
AbstractMarine micro-organisms in the deep-sea hydrothermal vent systems are considered as potential sources of bioactive natural products. Sixteen bacterial strains were isolated from a deep-sea hydrothermal field and screened for bioactive metabolism studies. After the strains were subjected to bioactive testing at different culture media, chemical dereplication by HPLC coupled to high-resolution mass spectrometer was performed to analyse or determine the main secondary metabolisms in those strains. Strain 06204 was large-scale fermented with relative optimal media, for isolating the desired sulphur compound. Butyrolactone I 3-sulphate was isolated and structurally identified from the extract, guided by dereplication and showed moderate antivirus activities against H3N2 and EV71 viruses. Our study suggests that deep-sea hydrothermal bacteria are good sources of sulphur natural products. Meanwhile, the described approach, mainly bioactive screening, dereplication and targeted isolation, is effective and efficient to discover interesting bioactive compounds in hydrothermal bacteria. [GRAPHICS] .
DepartmentLMB
KeywordHydrothermal bacteria dereplication targeted isolation antivirus butyrolactone I 3-sulphate
DOI10.1080/14786419.2017.1399382
Citation statistics
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17898
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, Guangdong Key Lab Marine Materia Med, Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou, Guangdong, Peoples R China
2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing, Peoples R China
3.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan, Hubei, Peoples R China
4.Guangzhou 6 Middle Sch, Guangzhou, Guangdong, Peoples R China
5.Shenzhen Univ, Shenzhen, Peoples R China
Recommended Citation
GB/T 7714
Lin, Xiuping,Li, Kunlong,Yang, Lilin,et al. Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field[J]. NATURAL PRODUCT RESEARCH,2019,33(4):494, 499.
APA Lin, Xiuping.,Li, Kunlong.,Yang, Lilin.,Peng, Xiaoying.,Fang, Wei.,...&Zhou, Xuefeng.(2019).Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field.NATURAL PRODUCT RESEARCH,33(4),494.
MLA Lin, Xiuping,et al."Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field".NATURAL PRODUCT RESEARCH 33.4(2019):494.
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