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Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus
Qiao, Yongjian; Yan, Jiayan; Jia, Jia1; Xue, Jiao; Qu, Xudong; Hu, Yunfeng2; Deng, Zixin; Bi, Hongkai1; Zhu, Dongqing
2019
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume82Issue:2Pages:318
AbstractArmeniaspirols (1-3) are potent antibiotics against Gram-positive pathogens. Through a biosynthetic investigation, we identified four enzymes involved in the structural modification of 1-3. Manipulation of their activity led to the generation of 4-6 and nine novel analogues, 7-15. Bioactivity assessments revealed that the pyrrole chloro group and the methyl group are important for the antimicrobial activities of armeniaspirols, which lays the foundation for future structure optimization and mechanism of action studies of armeniaspirols.
DepartmentLMB
DOI10.1021/acs.jnatprod.8b00753
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17906
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Wuhan Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Hubei, Peoples R China
2.Nanjing Med Univ, Dept Pathogen Biol, Nanjing 210029, Jiangsu, Peoples R China
3.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Qiao, Yongjian,Yan, Jiayan,Jia, Jia,et al. Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(2):318, 323.
APA Qiao, Yongjian.,Yan, Jiayan.,Jia, Jia.,Xue, Jiao.,Qu, Xudong.,...&Zhu, Dongqing.(2019).Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.JOURNAL OF NATURAL PRODUCTS,82(2),318.
MLA Qiao, Yongjian,et al."Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus".JOURNAL OF NATURAL PRODUCTS 82.2(2019):318.
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