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Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008
Luo Xiao-Wei; Lin Yun; Lu Yong-Jun; Zhou Xue-Feng; Liu Yong-Hong
2019
Source PublicationCHINESE JOURNAL OF NATURAL MEDICINES
ISSN2095-6975
Volume17Issue:2Pages:149
AbstractTwo new isomeric modified tripeptides, aspergillamides C and D (compounds 1 and 2), together with fifteen known compounds (compounds 3-17), were obtained from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. The structures of the new compounds, including absolute configurations, were determined by extensive analyses of spectroscopic data (NMR, MS, UV, and IR) and comparisons between the calculated and experimental electronic circular dichroism (ECD) spectra. Butyrolactone I (compound 11) exhibited strong inhibitory effects against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with the IC50 being 5.11 +/- 0.53 mu mol.L-1, and acted as a noncompetitive inhibitor based on kinetic analysis.
DepartmentLMB
KeywordAspergillus terreus Aspergillamides Polyketides MptpB inhibitor
DOI10.1016/S1875-5364(19)30017-2
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17910
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.[Luo Xiao-Wei
2.Zhou Xue-Feng
3.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China
4.[Luo Xiao-Wei
5.Zhou Xue-Feng
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
7.[Lin Yun
8.Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China
9.[Lin Yun
10.Sun Yat Sen Univ, Biomed Ctr, Guangzhou 510275, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Luo Xiao-Wei,Lin Yun,Lu Yong-Jun,et al. Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(2):149, 154.
APA Luo Xiao-Wei,Lin Yun,Lu Yong-Jun,Zhou Xue-Feng,&Liu Yong-Hong.(2019).Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008.CHINESE JOURNAL OF NATURAL MEDICINES,17(2),149.
MLA Luo Xiao-Wei,et al."Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008".CHINESE JOURNAL OF NATURAL MEDICINES 17.2(2019):149.
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