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Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium
Wang, Junfeng1; Qin, Li; Zhao, Biqing; Cai, Liang2; Zhong, Zhenping3; Liu, Yonghong1; Zhou, Xiaojiang
2019
Source PublicationORGANIC & BIOMOLECULAR CHEMISTRY
ISSN1477-0520
Volume17Issue:1Pages:195
AbstractCrotonols A and B (1 and 2), two tigliane diterpenoids featuring a rare C-7/C-14 cyclized and novel 5/7/7-fused carbon skeleton, along with the known tigliane wallichiioid A, were isolated from the leaves of Croton tiglium. Their structures were determined through spectroscopic methods, X-ray crystallography and ECD analysis. To the best of our knowledge, crotonol B (2) represents the first example of 13,14-seco-tigliane diterpenoids. Crotonols A and B displayed strong cytotoxic activities against the K562 cell line with IC50 values of 0.20 and 0.21 M, respectively. Furthermore, crotonol A promoted the apoptosis of K562 cells through the cleavage of PARP and the accumulation of bax as well as the degradation of bcl-2.
DepartmentLMB
DOI10.1039/c8ob02519c
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17919
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China
3.Hunan Prov Ctr Dis Control & Prevent, Changsha 410005, Hunan, Peoples R China
4.Yao Sheng Tang Hu Nan Pharmaceut Co Ltd, Anxiang 415600, Peoples R China
Recommended Citation
GB/T 7714
Wang, Junfeng,Qin, Li,Zhao, Biqing,et al. Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2019,17(1):195, 202.
APA Wang, Junfeng.,Qin, Li.,Zhao, Biqing.,Cai, Liang.,Zhong, Zhenping.,...&Zhou, Xiaojiang.(2019).Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium.ORGANIC & BIOMOLECULAR CHEMISTRY,17(1),195.
MLA Wang, Junfeng,et al."Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium".ORGANIC & BIOMOLECULAR CHEMISTRY 17.1(2019):195.
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