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Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399
Cong, Ziwen1; Huang, Xiaolong1; Liu, Yunhao; Liu, Yuxuan; Wang, Pei2; Liao, Shengrong; Yang, Bin; Zhou, Xuefeng; Huang, Dongyi1; Wang, Junfeng
2019
Source PublicationJOURNAL OF ANTIBIOTICS
ISSN0021-8820
Volume72Issue:1Pages:45
AbstractAranciamycin K (1) and isotirandamycin B (2) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives (3-6), and two known tirandamycin derivatives (7 and 8). Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and ECD calculation method. Most of the isolated compounds were tested for their cytotoxic, antibacterial, and antifungal activities. Compounds 2, 7 and 8 displayed potent bacteriostatic effects against Streptococcus agalactiae with MIC values of 11.5, 5.9 and 5.7 mu M, respectively. Besides, compounds 3, 5 and 6 exhibited moderate in vitro cytotoxic activities against the K562 cell lines with IC(50 )values of 22.0 +/- 0.20, 1.80 +/- 0.01 and 12.1 +/- 0.07 mu M, respectively.
DepartmentLMB
DOI10.1038/s41429-018-0103-6
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17929
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,CAS Key Lab Trop, Guangzhou 510301, Guangdong, Peoples R China
2.Hainan Univ, Inst Trop Agr & Forestry, Haikou 570228, Hainan, Peoples R China
3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Hainan, Peoples R China
Recommended Citation
GB/T 7714
Cong, Ziwen,Huang, Xiaolong,Liu, Yunhao,et al. Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399[J]. JOURNAL OF ANTIBIOTICS,2019,72(1):45, 49.
APA Cong, Ziwen.,Huang, Xiaolong.,Liu, Yunhao.,Liu, Yuxuan.,Wang, Pei.,...&Wang, Junfeng.(2019).Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399.JOURNAL OF ANTIBIOTICS,72(1),45.
MLA Cong, Ziwen,et al."Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399".JOURNAL OF ANTIBIOTICS 72.1(2019):45.
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