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A New Pentacyclic Ergosteroid from Fungus Aspergillus sp. SCSIO41211 Derived of Mangrove Sediment Sample
Tao, Huaming1; Li, Yunqiu2; Lin, Xiuping; Zhou, Xuefeng; Dong, Junde; Liu, Yonghong; Yang, Bin
2018
Source PublicationNATURAL PRODUCT COMMUNICATIONS
ISSN1934-578X
Volume13Issue:12Pages:1629
AbstractChemical investigation of the fungus Aspergillus sp. SCSIO41211 derived of mangrove sediment sample afforded a ergostane-type pentacyclic steroid, (22S, 23R)-12 alpha,14 alpha,23 alpha-trihydroxy-16,22-epoxy-ergosta-4,8-dien-3,11-dione (1), together with seven known compounds, flavacol (2), aspergilliamide (3), ochratoxin A methyl ester (4), ochratoxin A ethyl ester (5), dihydroaspyrone (6), aspilactonol E (7) and aspilactonol F (8). The structures were determined on the basis of NMR and MS analysis. The isolated compounds were tested for their antiviral activity against H3N2 and EV71 viruses, cytotoxic, and antituberculosis effects. Among them, compounds 2 and 5 showed significant cytotoxicity against ten human cancer cell lines. None of the compounds displayed a significant antiviral activity against H3N2 and EV71 viruses nor antimycobacterial activities.
DepartmentLMB
KeywordMarine-derived fungus Aspergillus Steroid Mycotoxins
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17931
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China
2.Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China
3.Guilin Med Univ, Coll Pharmaceut Sci, Guilin 541004, Peoples R China
Recommended Citation
GB/T 7714
Tao, Huaming,Li, Yunqiu,Lin, Xiuping,et al. A New Pentacyclic Ergosteroid from Fungus Aspergillus sp. SCSIO41211 Derived of Mangrove Sediment Sample[J]. NATURAL PRODUCT COMMUNICATIONS,2018,13(12):1629, 1631.
APA Tao, Huaming.,Li, Yunqiu.,Lin, Xiuping.,Zhou, Xuefeng.,Dong, Junde.,...&Yang, Bin.(2018).A New Pentacyclic Ergosteroid from Fungus Aspergillus sp. SCSIO41211 Derived of Mangrove Sediment Sample.NATURAL PRODUCT COMMUNICATIONS,13(12),1629.
MLA Tao, Huaming,et al."A New Pentacyclic Ergosteroid from Fungus Aspergillus sp. SCSIO41211 Derived of Mangrove Sediment Sample".NATURAL PRODUCT COMMUNICATIONS 13.12(2018):1629.
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