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Spirostaphylotrichin X from a Marine-Derived Fungus as an Anti-influenza Agent Targeting RNA Polymerase PB2
Wang, Jianjiao2; Chen, Feimin1; Liu, Yunhao5; Liu, Yuxuan5; Li, Kunlong; Yang, Xiliang3; Liu, Shuwen1,4; Zhou, Xuefeng4; Yang, Jie1
2018
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume81Issue:12Pages:2722
AbstractA new spirocyclic gamma-lactam, named spirostaphylotrichin X (1), and three related known spirostaphylotrichins (2-4) were isolated from the marine-derived fungus Cochliobolus lunatus SCSIO41401. Their structures were determined by spectroscopic analyses. Spirostaphylotrichin X (1) displayed obvious inhibitory activities against multiple influenza virus strains, with IC50 values from 1.2 to 5.5 mu M. Investigation of the mechanism showed that 1 inhibited viral polymerase activity and interfered with the production of progeny viral RNA. Homogeneous time-resolved fluorescence, surface plasmon resonance assays, and a molecular docking study revealed that 1 could inhibit polymerase PB2 protein activity by binding to the highly conserved region of the cap-binding domain of PB2. These results suggest that 1 inhibits the replication of influenza A virus by interfering with the activity of PB2 protein and that 1 represents a new type of potential lead compound for the development of anti-influenza therapeutics.
DepartmentLMB
DOI10.1021/acs.jnatprod.8b00656
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17932
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Materia Med, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China
2.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou Key Lab Drug Res Emerging Virus Prevent, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Wuhan Univ Sci & Technol, Med Coll, Dept Pharm, Wuhan 430065, Hubei, Peoples R China
5.Southern Med Univ, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China
6.Sun Yat Sen Univ, Middle Sch, Guangzhou, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jianjiao,Chen, Feimin,Liu, Yunhao,et al. Spirostaphylotrichin X from a Marine-Derived Fungus as an Anti-influenza Agent Targeting RNA Polymerase PB2[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(12):2722, 2730.
APA Wang, Jianjiao.,Chen, Feimin.,Liu, Yunhao.,Liu, Yuxuan.,Li, Kunlong.,...&Yang, Jie.(2018).Spirostaphylotrichin X from a Marine-Derived Fungus as an Anti-influenza Agent Targeting RNA Polymerase PB2.JOURNAL OF NATURAL PRODUCTS,81(12),2722.
MLA Wang, Jianjiao,et al."Spirostaphylotrichin X from a Marine-Derived Fungus as an Anti-influenza Agent Targeting RNA Polymerase PB2".JOURNAL OF NATURAL PRODUCTS 81.12(2018):2722.
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