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New citrinin derivatives from the deep-sea-derived fungus Cladosporium sp. SCSIO z015
Amin, Muhammad1; Zhang, Xiao-Yong; Xu, Xin-Ya; Qi, Shu-Hua
2020
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
Volume34Issue:9Pages:1219
AbstractDuring the course of our search for novel bioactive compounds from marine fungi, four new citrinin derivatives, cladosporins A-D (1-4) were isolated from a culture broth of the deep-sea-derived fungus Cladosporium sp. SCSIO z015. Their complete structural assignments were elucidated by the extensive spectroscopic investigation. The absolute configurations of 1-3 were established by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compounds 1-4 showed weak toxicity towards brine shrine naupalii with LC50 values of 72.0, 81.7, 49.9 and 81.4 mu M, respectively. And 4 also showed significant antioxidant activity against & x251;,alpha-diphenyl-picrylhydrazyl (DPPH) radicals with an IC50 value of 16.4 mu M.
DepartmentLMB
KeywordDeep-sea-derived fungus Cladosporium sp SCSIO z015 citrinin derivative toxicity antioxidant
Funding OrganizationNatural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81673326]; Strategic Leading Special Science and Technology Program of Chinese Academy of Sciences [XDA100304002]; Regional Innovation Demonstration Project of Guangdong Province Marine Economic Development [GD2012-D01-002]; CAS-TWAS President's Fellowship for International PhD Students ; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81673326]; Strategic Leading Special Science and Technology Program of Chinese Academy of Sciences [XDA100304002]; Regional Innovation Demonstration Project of Guangdong Province Marine Economic Development [GD2012-D01-002]; CAS-TWAS President's Fellowship for International PhD Students
DOI10.1080/14786419.2018.1556266
Funding OrganizationNatural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81673326]; Strategic Leading Special Science and Technology Program of Chinese Academy of Sciences [XDA100304002]; Regional Innovation Demonstration Project of Guangdong Province Marine Economic Development [GD2012-D01-002]; CAS-TWAS President's Fellowship for International PhD Students ; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81673326]; Strategic Leading Special Science and Technology Program of Chinese Academy of Sciences [XDA100304002]; Regional Innovation Demonstration Project of Guangdong Province Marine Economic Development [GD2012-D01-002]; CAS-TWAS President's Fellowship for International PhD Students
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Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/18432
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou, Guangdong, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Amin, Muhammad,Zhang, Xiao-Yong,Xu, Xin-Ya,et al. New citrinin derivatives from the deep-sea-derived fungus Cladosporium sp. SCSIO z015[J]. NATURAL PRODUCT RESEARCH,2020,34(9):1219, 1226.
APA Amin, Muhammad,Zhang, Xiao-Yong,Xu, Xin-Ya,&Qi, Shu-Hua.(2020).New citrinin derivatives from the deep-sea-derived fungus Cladosporium sp. SCSIO z015.NATURAL PRODUCT RESEARCH,34(9),1219.
MLA Amin, Muhammad,et al."New citrinin derivatives from the deep-sea-derived fungus Cladosporium sp. SCSIO z015".NATURAL PRODUCT RESEARCH 34.9(2020):1219.
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