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Engineered Biosynthesis of 5/5/6 Type Polycyclic Tetramate Macrolactams in an Ikarugamycin (5/6/5 Type)-Producing Chassis
Jin, Hongbo1; Zhang, Wenjun; Zhang, Guangtao; Zhang, Liping; Liu, Wei2; Zhang, Changsheng
2020
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume22Issue:5Pages:1731
AbstractCombinatorial biosynthesis of 5/5/6 type polycyclic tetramate macrolactams (PoTeMs) was achieved in an engineered ikarugamycin (5/6/5 type) producer by introducing a set of 5/5/6 type PoTeM biosynthetic genes from Streptornyces griseus. This study supports the idea that PoTeMs share a common polyene tetramate precursor generated by the hybrid polyketide synthase/nonribosomal peptide synthetase enzymes. The X-ray crystal structure of pactamide G (7) sets an example for resolving the absolute configuration of 5/5/6 type PoTeMs.
DepartmentLMB
Funding OrganizationNSFCNational Natural Science Foundation of China (NSFC) [31630004, 41911530078, 41606193]; MOST [2018YFC1406705]; Chinese Academy of SciencesChinese Academy of Sciences [QYZDJ-SSW-DQC004, XDA13020302] ; NSFCNational Natural Science Foundation of China (NSFC) [31630004, 41911530078, 41606193]; MOST [2018YFC1406705]; Chinese Academy of SciencesChinese Academy of Sciences [QYZDJ-SSW-DQC004, XDA13020302]
DOI10.1021/acs.orglett.9b04672
Funding OrganizationNSFCNational Natural Science Foundation of China (NSFC) [31630004, 41911530078, 41606193]; MOST [2018YFC1406705]; Chinese Academy of SciencesChinese Academy of Sciences [QYZDJ-SSW-DQC004, XDA13020302] ; NSFCNational Natural Science Foundation of China (NSFC) [31630004, 41911530078, 41606193]; MOST [2018YFC1406705]; Chinese Academy of SciencesChinese Academy of Sciences [QYZDJ-SSW-DQC004, XDA13020302]
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/18479
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,Key Lab Trop Mar, Guangzhou 510301, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Sun Yat Sen Univ, South China Sea Resource Exploitat & Protect Coll, Sch Marine Sci, Guangzhou 510006, Peoples R China
Recommended Citation
GB/T 7714
Jin, Hongbo,Zhang, Wenjun,Zhang, Guangtao,et al. Engineered Biosynthesis of 5/5/6 Type Polycyclic Tetramate Macrolactams in an Ikarugamycin (5/6/5 Type)-Producing Chassis[J]. ORGANIC LETTERS,2020,22(5):1731, 1735.
APA Jin, Hongbo,Zhang, Wenjun,Zhang, Guangtao,Zhang, Liping,Liu, Wei,&Zhang, Changsheng.(2020).Engineered Biosynthesis of 5/5/6 Type Polycyclic Tetramate Macrolactams in an Ikarugamycin (5/6/5 Type)-Producing Chassis.ORGANIC LETTERS,22(5),1731.
MLA Jin, Hongbo,et al."Engineered Biosynthesis of 5/5/6 Type Polycyclic Tetramate Macrolactams in an Ikarugamycin (5/6/5 Type)-Producing Chassis".ORGANIC LETTERS 22.5(2020):1731.
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