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HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17
Luo, Xiao-Wei; Gao, Cheng-Hai; Lu, Hu-Mu; Wang, Jia-Min; Su, Zi-Qi; Tao, Hua-Ming; Zhou, Xue-Feng; Yang, Bin; Liu, Yong-Hong
2020
Source PublicationMOLECULES
Volume25Issue:5Pages:1237
AbstractCytochalasans have continuously aroused considerable attention among the chemistry and pharmacology communities due to their structural complexities and pharmacological significances. Sixteen structurally diverse chaetoglobosins, 10-(indol-3-yl)-[13]cytochalasans, including a new one, 6-O-methyl-chaetoglobosin Q (1), were isolated from the coral-associated fungus Chaetomium globosum C2F17. Their structures were accomplished by extensive spectroscopic analysis combined with single-crystal X-ray crystallography and ECD calculations. Meanwhile, the structures and absolute configurations of the previously reported compounds 6, 12, and 13 were confirmed by single-crystal X-ray analysis for the first time. Chaetoglobosins E (6) and Fex (11) showed significant cytotoxicity against a panel of cancer cell lines, K562, A549, Huh7, H1975, MCF-7, U937, BGC823, HL60, Hela, and MOLT-4, with the IC50 values ranging from 1.4 mu M to 9.2 mu M.
DepartmentLMB
Keywordcoral marine fungi Chaetomium globosum cytochalasans chaetoglobosins cytotoxicity
Funding OrganizationGuangdong Basic and Applied Basic Research Foundation [2018A0303130219, 2019B151502042]; Special Fund for Bagui Scholars of Guangxi; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772210, 81973235, 21977102]; Development Program of High-level Talent Team under Qihuang Project of Guangxi University of Chinese Medicine (GXUCM) [2018006]; Initial Scientific Research Foundation of Introduced Doctors in 2019 of GXUCM [2019BS021]; Scientific Research Foundation of Institute of Marine Drugs, GXUCM [2018ZD005-A01, 2018ZD005-A17]; Guangdong MEPP Funds [GDOE [2019]A28]; Key Project of Science and Technology Department of Guangxi [AB16380009]; GBABRF [2018A0303130219] ; Guangdong Basic and Applied Basic Research Foundation [2018A0303130219, 2019B151502042]; Special Fund for Bagui Scholars of Guangxi; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772210, 81973235, 21977102]; Development Program of High-level Talent Team under Qihuang Project of Guangxi University of Chinese Medicine (GXUCM) [2018006]; Initial Scientific Research Foundation of Introduced Doctors in 2019 of GXUCM [2019BS021]; Scientific Research Foundation of Institute of Marine Drugs, GXUCM [2018ZD005-A01, 2018ZD005-A17]; Guangdong MEPP Funds [GDOE [2019]A28]; Key Project of Science and Technology Department of Guangxi [AB16380009]; GBABRF [2018A0303130219]
DOI10.3390/molecules25051237
Funding OrganizationGuangdong Basic and Applied Basic Research Foundation [2018A0303130219, 2019B151502042]; Special Fund for Bagui Scholars of Guangxi; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772210, 81973235, 21977102]; Development Program of High-level Talent Team under Qihuang Project of Guangxi University of Chinese Medicine (GXUCM) [2018006]; Initial Scientific Research Foundation of Introduced Doctors in 2019 of GXUCM [2019BS021]; Scientific Research Foundation of Institute of Marine Drugs, GXUCM [2018ZD005-A01, 2018ZD005-A17]; Guangdong MEPP Funds [GDOE [2019]A28]; Key Project of Science and Technology Department of Guangxi [AB16380009]; GBABRF [2018A0303130219] ; Guangdong Basic and Applied Basic Research Foundation [2018A0303130219, 2019B151502042]; Special Fund for Bagui Scholars of Guangxi; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772210, 81973235, 21977102]; Development Program of High-level Talent Team under Qihuang Project of Guangxi University of Chinese Medicine (GXUCM) [2018006]; Initial Scientific Research Foundation of Introduced Doctors in 2019 of GXUCM [2019BS021]; Scientific Research Foundation of Institute of Marine Drugs, GXUCM [2018ZD005-A01, 2018ZD005-A17]; Guangdong MEPP Funds [GDOE [2019]A28]; Key Project of Science and Technology Department of Guangxi [AB16380009]; GBABRF [2018A0303130219]
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/18485
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.[Luo, Xiao-Wei
2.Gao, Cheng-Hai
3.Lu, Hu-Mu
4.Guangxi Univ Chinese Med, Inst Marine Drugs, Nanning 530200, Peoples R China
5.[Wang, Jia-Min
6.Zhou, Xue-Feng
7.Yang, Bin
8.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Peoples R China
9.[Su, Zi-Qi
10.Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China
Recommended Citation
GB/T 7714
Luo, Xiao-Wei,Gao, Cheng-Hai,Lu, Hu-Mu,et al. HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17[J]. MOLECULES,2020,25(5):1237.
APA Luo, Xiao-Wei.,Gao, Cheng-Hai.,Lu, Hu-Mu.,Wang, Jia-Min.,Su, Zi-Qi.,...&Liu, Yong-Hong.(2020).HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17.MOLECULES,25(5),1237.
MLA Luo, Xiao-Wei,et al."HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17".MOLECULES 25.5(2020):1237.
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