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学科主题: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
题名: Antifungal Cyclic Peptides from Psammosilene tunicoides
作者: Tian, JM ; Shen, YH ; Yang, XW ; Liang, SA ; Shan, L ; Li, HL ; Liu, RH ; Zhang, WD
通讯作者: shenyunheng9217018@yahoo.com.cn ; wdzhangy@hotmail.com
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2010
卷: 73, 期:12, 页:1987-1992
收录类别: sci
部门归属: [Tian, Junmian; Shen, Yunheng; Yang, Xianwen; Shan, Lei; Li, Huiliang; Liu, Runhui; Zhang, Weidong] Mil Med Coll 2, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China; [Yang, Xianwen] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China; [Liang, Shuang; Zhang, Weidong] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Liang, Shuang] Shanghai Univ Tradit Chinese Med, Engn Res Ctr Modern Preparat Technol TCM, Minist Educ, Shanghai 201203, Peoples R China
项目归属: LMB
摘要: Three new cyclic peptides, tunicyclins B-D, and a known cyclic peptide, psammosilenin B, were isolated from the root of Psammosilene tunicoides. The structures of new cyclic peptides were elucidated by extensive NMR and MS analysis. Tunicyclin B contains an unusual alpha,beta-dehydrotryptophan (Delta(Z)-Trp) residue, previously reported from marine sponges and bacteria. Tunicyclin D showed a broad spectrum of antifungal activity against Candida albicans (SC5314), Candida albicans (Y0109), Candida tropicalis, Candida parapsilosis, and Cryptococcus neoformans (BLS 108) with MIC80 values of 4.0, 16.0, 0.25, 1.0, and 1.0 mu g mL(-1), respectively.
原文出处: 查看原文
WOS记录号: WOS:000285560000003
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/3712
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Tian, JM; Shen, YH; Yang, XW; Liang, SA; Shan, L; Li, HL; Liu, RH; Zhang, WD.Antifungal Cyclic Peptides from Psammosilene tunicoides,JOURNAL OF NATURAL PRODUCTS,2010,73(12):1987-1992
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