Diterpenoid Constituents of the Roots of Salvia digitaloides
Xu, G; Yang, J; Wang, YY; Peng, LY; Yang, XW; Pan, ZH; Liu, ED; Li, Y; Zhao, QS; xugang008@mail.kib.ac.cn; qinshizhao@mail.kib.ac.cn
2010
发表期刊JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
卷号58期号:23页码:12157-12161
摘要Salvia digitaloides, belonging to the economically and medicinally important genus Salvia, is distributed in the northwest of Yunnan Province, People's Republic of China. The roots of this plant were soaked in alcohol by local Tibetans to make a special traditional "red wine", and many local people like to drink this traditional "red wine" to strengthen physical health. To investigate the bioactive diterpenoid constituents of the roots, a detailed phytochemical study was carried out, and 13 diterpenoids including two new norditerpenoids, dihydroneotanshinlactone (1) and 16,17-dinorpisferal A (2), were isolated. Their structures were established on the basis of detailed spectroscopic analysis. In addition, computational methods were applied to validate the stereochemistry of compound 1. For the bioassay to inhibit the growth of five tumor cell lines, neotanshinlactone (3) exhibited selective cytotoxic activity toward the human breast cancer cell line SK-BR-3, while the other four tanshinones (4-7) showed significant toxicity effects against all of the tested five cell lines.
部门归属[Xu, Gang; Wang, Yuan-Yuan; Peng, Li-Yan; Pan, Zheng-Hong; Liu, En-De; Li, Yan; Zhao, Qin-Shi] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China; [Yang, Jing] Shanghai Jiao Tong Univ, Sch Chem & Chem Technol, Shanghai 200240, Peoples R China; [Yang, Xian-Wen] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
关键词Salvia Digitaloides Cytotoxic Activity Diterpenoids Stereochemistry
学科领域Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
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收录类别sci
资助项目LMB
WOS记录号WOS:000284672800015
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/3722
专题中科院海洋生物资源可持续利用重点实验室
通讯作者xugang008@mail.kib.ac.cn; qinshizhao@mail.kib.ac.cn
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Xu, G,Yang, J,Wang, YY,et al. Diterpenoid Constituents of the Roots of Salvia digitaloides[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2010,58(23):12157-12161.
APA Xu, G.,Yang, J.,Wang, YY.,Peng, LY.,Yang, XW.,...&qinshizhao@mail.kib.ac.cn.(2010).Diterpenoid Constituents of the Roots of Salvia digitaloides.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,58(23),12157-12161.
MLA Xu, G,et al."Diterpenoid Constituents of the Roots of Salvia digitaloides".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 58.23(2010):12157-12161.
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