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学科主题: Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic
题名: Bioprospecting for antituberculosis leads from microbial metabolites
作者: Ashforth, EJ ; Fu, CZ ; Liu, XY ; Dai, HQ ; Song, FH ; Guo, H ; Zhang, LX
通讯作者: zhanglixin@im.ac.cn
刊名: NATURAL PRODUCT REPORTS
发表日期: 2010
卷: 27, 期:11, 页:1709-1719
收录类别: sci
部门归属: [Ashforth, Elizabeth Jane; Fu, Chengzhang; Liu, Xiangyang; Dai, Huanqin; Song, Fuhang; Guo, Hui; Zhang, Lixin] Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China; [Zhang, Lixin] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Fu, Chengzhang; Guo, Hui] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
项目归属: LMB
摘要: Microbial metabolites have been an important source of tuberculosis (TB) therapeutics, but the last truly novel drug that was approved for the treatment of TB was discovered 40 years ago. In light of the growing threat of multi-drug resistance, recent advances have been made to accelerate the discovery rate of novel TB drugs including diversifying strategies for environmental strains, and high-throughput screening assays. This review will discuss the approaches used in biodiversity- and taxonomy-guided microbial natural product library construction, specific cell-based and target-based high-throughput screening assays and early-stage dereplication processes by liquid chromatography-mass spectrometry (LC-MS). New antituberculosis natural products that have been recently discovered are highlighted.
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WOS记录号: WOS:000283312100008
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/3742
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Ashforth, EJ; Fu, CZ; Liu, XY; Dai, HQ; Song, FH; Guo, H; Zhang, LX.Bioprospecting for antituberculosis leads from microbial metabolites,NATURAL PRODUCT REPORTS,2010,27(11):1709-1719
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文件名: Bioprospecting microbial natural product libraries from the marine environment for drug discovery .pdf
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