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学科主题: Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy
题名: A Novel Cyclopentene Derivative and a Polyhydroxylated Steroid from a South China Sea Gorgonian Menella sp.
作者: Chai, XY ; Sun, JF ; Tang, LY ; Yang, XW ; Li, YQ ; Huang, H ; Zhou, XF ; Yang, B ; Liu, YH
通讯作者: yonghongliu@scsio.ac.cn
关键词: Menella sp. ; gorgonian ; menell in A ; menellsteroid C ; X-ray diffraction ; anti-inflammatory inhibition
刊名: CHEMICAL & PHARMACEUTICAL BULLETIN
发表日期: 2010
卷: 58, 期:10, 页:1391-1394
收录类别: sci
部门归属: [Chai, Xing-Yun; Sun, Jian-Fan; Yang, Xian-Wen; Li, Yun-Qiu; Huang, Hui; Zhou, Xue-Feng; Yang, Bin; Liu, Yonghong] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, Res Ctr Marine Microbes,S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Tang, Li-Ying] Chinese Acad Med Sci, Inst Tradit Chinese Mat Med, Beijing 100700, Peoples R China; [Huang, Hui] Natl Expt Stn Trop Marine Biol, Sanya 572000, Peoples R China
项目归属: LMB
摘要: A chemical investigation on a South China Sea gorgonian, Menella sp. resulted in the isolation and elucidation of menellin A (1), a highly oxygenated racemate with C skeleton, and a polyhydroxylated steroid, menellsteroid C (2), along with eight known compounds (3-10). The structures of the new compounds were elucidated by means of MS, 1D and 2D NMR spectra, and the relative stereochemistry of 1 was determined by X-ray single-crystal diffraction analysis. In addition, compound 7 was isolated as a new natural product. Compounds 1-3 and 7 were selected to test the anti-inflammatory inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. 1 and 3 exhibited modest inhibitory effects with IC50 of 71.3, 33.9 mu M, respectively, compared to the positive control aminoguanidine (IC50 25.0 mu M).
原文出处: 查看原文
WOS记录号: WOS:000282419600019
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/3758
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Chai, XY; Sun, JF; Tang, LY; Yang, XW; Li, YQ; Huang, H; Zhou, XF; Yang, B; Liu, YH.A Novel Cyclopentene Derivative and a Polyhydroxylated Steroid from a South China Sea Gorgonian Menella sp.,CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(10):1391-1394
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