A Novel Cyclopentene Derivative and a Polyhydroxylated Steroid from a South China Sea Gorgonian Menella sp.
Chai, XY; Sun, JF; Tang, LY; Yang, XW; Li, YQ; Huang, H; Zhou, XF; Yang, B; Liu, YH; yonghongliu@scsio.ac.cn
2010
发表期刊CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN0009-2363
卷号58期号:10页码:1391-1394
摘要A chemical investigation on a South China Sea gorgonian, Menella sp. resulted in the isolation and elucidation of menellin A (1), a highly oxygenated racemate with C skeleton, and a polyhydroxylated steroid, menellsteroid C (2), along with eight known compounds (3-10). The structures of the new compounds were elucidated by means of MS, 1D and 2D NMR spectra, and the relative stereochemistry of 1 was determined by X-ray single-crystal diffraction analysis. In addition, compound 7 was isolated as a new natural product. Compounds 1-3 and 7 were selected to test the anti-inflammatory inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. 1 and 3 exhibited modest inhibitory effects with IC50 of 71.3, 33.9 mu M, respectively, compared to the positive control aminoguanidine (IC50 25.0 mu M).
部门归属[Chai, Xing-Yun; Sun, Jian-Fan; Yang, Xian-Wen; Li, Yun-Qiu; Huang, Hui; Zhou, Xue-Feng; Yang, Bin; Liu, Yonghong] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, Res Ctr Marine Microbes,S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Tang, Li-Ying] Chinese Acad Med Sci, Inst Tradit Chinese Mat Med, Beijing 100700, Peoples R China; [Huang, Hui] Natl Expt Stn Trop Marine Biol, Sanya 572000, Peoples R China
关键词Menella Sp. Gorgonian Menell In a Menellsteroid c X-ray Diffraction Anti-inflammatory Inhibition
学科领域Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
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收录类别sci
资助项目LMB
WOS记录号WOS:000282419600019
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/3758
专题中科院海洋生物资源可持续利用重点实验室
通讯作者yonghongliu@scsio.ac.cn
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Chai, XY,Sun, JF,Tang, LY,et al. A Novel Cyclopentene Derivative and a Polyhydroxylated Steroid from a South China Sea Gorgonian Menella sp.[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(10):1391-1394.
APA Chai, XY.,Sun, JF.,Tang, LY.,Yang, XW.,Li, YQ.,...&yonghongliu@scsio.ac.cn.(2010).A Novel Cyclopentene Derivative and a Polyhydroxylated Steroid from a South China Sea Gorgonian Menella sp..CHEMICAL & PHARMACEUTICAL BULLETIN,58(10),1391-1394.
MLA Chai, XY,et al."A Novel Cyclopentene Derivative and a Polyhydroxylated Steroid from a South China Sea Gorgonian Menella sp.".CHEMICAL & PHARMACEUTICAL BULLETIN 58.10(2010):1391-1394.
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