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学科主题: Biotechnology & Applied Microbiology; Immunology; Microbiology; Pharmacology & Pharmacy
题名: Bioprospecting microbial natural product libraries from the marine environment for drug discovery
作者: Liu, XY ; Ashforth, E ; Ren, BA ; Song, FH ; Dai, HQ ; Liu, M ; Wang, JA ; Xie, QO ; Zhang, LX
关键词: antibiotic discovery ; dereplication ; diversity ; high-throughput screening ; marine actinomycetes ; natural product library ; systematics
刊名: JOURNAL OF ANTIBIOTICS
发表日期: 2010
卷: 63, 期:8, 页:415-422
收录类别: sci
部门归属: [Xie, Qiong] China Astronaut Res & Training Ctr, Beijing, Peoples R China; [Liu, Xiangyang; Ashforth, Elizabeth; Ren, Biao; Song, Fuhang; Dai, Huanqin; Liu, Mei; Wang, Jian; Zhang, Lixin] Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China; [Ren, Biao] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China; [Wang, Jian; Zhang, Lixin] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China
项目归属: LMB
摘要: Marine microorganisms are fascinating resources due to their production of novel natural products with antimicrobial activities. Increases in both the number of new chemical entities found and the substantiation of indigenous marine actinobacteria present a fundamental difficulty in the future discovery of novel antimicrobials, namely dereplication of those compounds already discovered. This review will share our experience on the taxonomic-based construction of a highly diversified and low redundant marine microbial natural product library for high-throughput antibiotic screening. We anticipate that libraries such as these can drive the drug discovery process now and in the future. The Journal of Antibiotics (2010) 63, 415-422, doi:10 1038/ja.2010.56; published online 7 July 2010
原文出处: 查看原文
WOS记录号: WOS:000281499800003
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/3776
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Liu, XY; Ashforth, E; Ren, BA; Song, FH; Dai, HQ; Liu, M; Wang, JA; Xie, QO; Zhang, LX.Bioprospecting microbial natural product libraries from the marine environment for drug discovery,JOURNAL OF ANTIBIOTICS,2010,63(8):415-422
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