Bioprospecting microbial natural product libraries from the marine environment for drug discovery
Liu, XY; Ashforth, E; Ren, BA; Song, FH; Dai, HQ; Liu, M; Wang, JA; Xie, QO; Zhang, LX
2010
发表期刊JOURNAL OF ANTIBIOTICS
ISSN0021-8820
卷号63期号:8页码:415-422
摘要Marine microorganisms are fascinating resources due to their production of novel natural products with antimicrobial activities. Increases in both the number of new chemical entities found and the substantiation of indigenous marine actinobacteria present a fundamental difficulty in the future discovery of novel antimicrobials, namely dereplication of those compounds already discovered. This review will share our experience on the taxonomic-based construction of a highly diversified and low redundant marine microbial natural product library for high-throughput antibiotic screening. We anticipate that libraries such as these can drive the drug discovery process now and in the future. The Journal of Antibiotics (2010) 63, 415-422, doi:10 1038/ja.2010.56; published online 7 July 2010
部门归属[Xie, Qiong] China Astronaut Res & Training Ctr, Beijing, Peoples R China; [Liu, Xiangyang; Ashforth, Elizabeth; Ren, Biao; Song, Fuhang; Dai, Huanqin; Liu, Mei; Wang, Jian; Zhang, Lixin] Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China; [Ren, Biao] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China; [Wang, Jian; Zhang, Lixin] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China
关键词Antibiotic Discovery Dereplication Diversity High-throughput Screening Marine Actinomycetes Natural Product Library Systematics
学科领域Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
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收录类别sci
资助项目LMB
WOS记录号WOS:000281499800003
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被引频次:50[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/3776
专题中科院海洋生物资源可持续利用重点实验室
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Liu, XY,Ashforth, E,Ren, BA,et al. Bioprospecting microbial natural product libraries from the marine environment for drug discovery[J]. JOURNAL OF ANTIBIOTICS,2010,63(8):415-422.
APA Liu, XY.,Ashforth, E.,Ren, BA.,Song, FH.,Dai, HQ.,...&Zhang, LX.(2010).Bioprospecting microbial natural product libraries from the marine environment for drug discovery.JOURNAL OF ANTIBIOTICS,63(8),415-422.
MLA Liu, XY,et al."Bioprospecting microbial natural product libraries from the marine environment for drug discovery".JOURNAL OF ANTIBIOTICS 63.8(2010):415-422.
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