中国科学院南海海洋研究所机构知识库
Advanced  
SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室  > 期刊论文
学科主题: Biotechnology & Applied Microbiology; Immunology; Microbiology; Pharmacology & Pharmacy
题名: Staphylococcus aureus promoter-lux reporters for drug discovery
作者: Mesak, LR ; Qi, SH ; Villanueva, I ; Miao, V ; Davies, J
关键词: actinomycete ; antibiotic profiling/fingerprint ; luciferase ; promoter-lux reporter ; Staphylococcus aureus
刊名: JOURNAL OF ANTIBIOTICS
发表日期: 2010
卷: 63, 期:8, 页:492-498
收录类别: sci
部门归属: [Mesak, Lili R.; Villanueva, Ivan; Miao, Vivian; Davies, Julian] Univ British Columbia, Inst Life Sci, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada; [Qi, Shuhua] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, Guangzhou, Guangdong, Peoples R China
项目归属: LMB
摘要: We describe a collection of antibiotic-activated Staphylococcus aureus promoter-lux reporter strains that can be used to discriminate among antibiotic classes on the basis of their light production response profile. We screened over 400 culture supernatants from previously uncharacterized actinomycetes from soil for the production of aminocoumarin-type compounds and DNA-damaging agents. Novobiocin production was determined in three isolates of Streptomyces, and streptonigrin, a DNA-damaging agent, together with several other bioactive compounds (oxopropaline D and G), was identified from a novel Kitasatospora isolate. This array provides an effective and specific whole-cell approach to search for classes of antimicrobial compounds in unfractionated culture broths. The Journal of Antibiotics (2010) 63, 492-498, doi 10 1038/ja 2010 74, published online 7 July 2010
原文出处: 查看原文
WOS记录号: WOS:000281499800013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/3778
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

Files in This Item:

There are no files associated with this item.


Recommended Citation:
Mesak, LR; Qi, SH; Villanueva, I; Miao, V; Davies, J.Staphylococcus aureus promoter-lux reporters for drug discovery,JOURNAL OF ANTIBIOTICS,2010,63(8):492-498
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Mesak, LR]'s Articles
[Qi, SH]'s Articles
[Villanueva, I]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Mesak, LR]‘s Articles
[Qi, SH]‘s Articles
[Villanueva, I]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院南海海洋研究所 - Feedback
Powered by CSpace