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学科主题: Biochemistry & Molecular Biology
题名: Structure elucidation and immunological activity of a novel polysaccharide from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.) S. Ito.
作者: Han, XQ ; Chai, XY ; Jia, YM ; Han, CX ; Tu, PF
通讯作者: pengfeitu@vip.163.com
关键词: Sarcodon aspratus (Berk.) S. Ito. ; Edible mushroom ; Polysaccharide ; Glucan ; Immunological activity
刊名: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
发表日期: 2010
卷: 47, 期:3, 页:420-424
收录类别: sci
部门归属: [Han, Xiao-Qiang; Chai, Xing-Yun; Jia, Ya-Min; Tu, Peng-Fei] Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China; [Chai, Xing-Yun] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Han, Chun-Xia] Dionex China Ltd, Applicat Ctr, Beijing 100085, Peoples R China
项目归属: LMB
摘要: A water-soluble polysaccharide with a molar weight of 4.3 x 10(5) Da, termed as HBP was isolated from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.) S. Ito. Composition, methylation analysis, Fourier transform infrared spectroscopy, and nuclear magnetic resonance spectroscopy experiments were conducted to elucidate its structure. The results indicated that HBP is a glucan featuring a backbone of (1 -> 6)-linked-beta-D-glucopyranosyl residues, which occasionally branched at O-3 position on along the backbone and substituted by the side chains that consisting of (1 -> 3)-linked-beta-D-glucopyranosyl, (1 -> 4)-linked-beta-D-glucopyranosyl and non-reducing end beta-D-glucopyranosyl residues. Immunological activity evaluation by H-3-thymidine incorporation method revealed that HBP can significantly stimulate the proliferation of the cultured mice spleen lymphocyte in a dose-dependent manner, thus, HBP is a promising potential immunomodulator that can be used as healthcare food or medicine against pathogens and tumors. (C) 2010 Elsevier B.V. All rights reserved.
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WOS记录号: WOS:000281490500016
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/3780
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Han, XQ; Chai, XY; Jia, YM; Han, CX; Tu, PF.Structure elucidation and immunological activity of a novel polysaccharide from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.) S. Ito.,INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2010,47(3):420-424
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