Trichodermaketones A-D and 7-O-Methylkoninginin D from the Marine Fungus Trichoderma koningii
Song, FH; Dai, HQ; Tong, YJ; Ren, BA; Chen, CX; Sun, N; Liu, XY; Bian, J; Liu, M; Gao, H; Liu, HW; Chen, XP; Zhang, LX; zhanglixin@im.ac.cn
2010
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号73期号:5页码:806-810
摘要Five new polyketide derivatives, 7-O-methylkoninginin D (1) and trichodermaketones A-D (2-5), together with four known compounds, koninginins A, D, E, and F, were isolated from the marine-derived fungus Trichoderma koningii. Trichodermaketones A (2) and B (3) are unprecedented polyketides with a bistetrafuran-containing tricyclic skeleton. The chemical structures and absolute configurations of compounds 1-5 were elucidated by comparing with literature data and extensive spectroscopic methods, including 2D NMR and CD spectroscopic analysis. Compounds 1-5 were evaluated for action against bacteria and fungi and for synergistic antifungal activity. Compound 2 showed synergistic antifungal activity against Candida albicans with 0.05 mu g/mL ketoconazole.
部门归属[Song, Fuhang; Dai, Huanqin; Tong, Yaojun; Ren, Biao; Chen, Caixia; Sun, Nuo; Liu, Xiangyang; Bian, Jiang; Liu, Mei; Gao, Hong; Liu, Hongwei; Zhang, Lixin] Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China; [Zhang, Lixin] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Chen, Xiaoping; Zhang, Lixin] Chinese Acad Sci, Guangzhou Inst Biomed, Guangzhou 510663, Guangdong, Peoples R China; [Chen, Xiaoping; Zhang, Lixin] Chinese Acad Sci, Guangzhou Inst Hlth, Guangzhou 510663, Guangdong, Peoples R China; [Tong, Yaojun; Ren, Biao; Bian, Jiang] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
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收录类别sci
资助项目LMB
WOS记录号WOS:000278080900003
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/3826
专题中科院海洋生物资源可持续利用重点实验室
通讯作者zhanglixin@im.ac.cn
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GB/T 7714
Song, FH,Dai, HQ,Tong, YJ,et al. Trichodermaketones A-D and 7-O-Methylkoninginin D from the Marine Fungus Trichoderma koningii[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(5):806-810.
APA Song, FH.,Dai, HQ.,Tong, YJ.,Ren, BA.,Chen, CX.,...&zhanglixin@im.ac.cn.(2010).Trichodermaketones A-D and 7-O-Methylkoninginin D from the Marine Fungus Trichoderma koningii.JOURNAL OF NATURAL PRODUCTS,73(5),806-810.
MLA Song, FH,et al."Trichodermaketones A-D and 7-O-Methylkoninginin D from the Marine Fungus Trichoderma koningii".JOURNAL OF NATURAL PRODUCTS 73.5(2010):806-810.
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