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学科主题: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
题名: Trichodermaketones A-D and 7-O-Methylkoninginin D from the Marine Fungus Trichoderma koningii
作者: Song, FH ; Dai, HQ ; Tong, YJ ; Ren, BA ; Chen, CX ; Sun, N ; Liu, XY ; Bian, J ; Liu, M ; Gao, H ; Liu, HW ; Chen, XP ; Zhang, LX
通讯作者: zhanglixin@im.ac.cn
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2010
卷: 73, 期:5, 页:806-810
收录类别: sci
部门归属: [Song, Fuhang; Dai, Huanqin; Tong, Yaojun; Ren, Biao; Chen, Caixia; Sun, Nuo; Liu, Xiangyang; Bian, Jiang; Liu, Mei; Gao, Hong; Liu, Hongwei; Zhang, Lixin] Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China; [Zhang, Lixin] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Chen, Xiaoping; Zhang, Lixin] Chinese Acad Sci, Guangzhou Inst Biomed, Guangzhou 510663, Guangdong, Peoples R China; [Chen, Xiaoping; Zhang, Lixin] Chinese Acad Sci, Guangzhou Inst Hlth, Guangzhou 510663, Guangdong, Peoples R China; [Tong, Yaojun; Ren, Biao; Bian, Jiang] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
项目归属: LMB
摘要: Five new polyketide derivatives, 7-O-methylkoninginin D (1) and trichodermaketones A-D (2-5), together with four known compounds, koninginins A, D, E, and F, were isolated from the marine-derived fungus Trichoderma koningii. Trichodermaketones A (2) and B (3) are unprecedented polyketides with a bistetrafuran-containing tricyclic skeleton. The chemical structures and absolute configurations of compounds 1-5 were elucidated by comparing with literature data and extensive spectroscopic methods, including 2D NMR and CD spectroscopic analysis. Compounds 1-5 were evaluated for action against bacteria and fungi and for synergistic antifungal activity. Compound 2 showed synergistic antifungal activity against Candida albicans with 0.05 mu g/mL ketoconazole.
原文出处: 查看原文
WOS记录号: WOS:000278080900003
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/3826
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Song, FH; Dai, HQ; Tong, YJ; Ren, BA; Chen, CX; Sun, N; Liu, XY; Bian, J; Liu, M; Gao, H; Liu, HW; Chen, XP; Zhang, LX.Trichodermaketones A-D and 7-O-Methylkoninginin D from the Marine Fungus Trichoderma koningii,JOURNAL OF NATURAL PRODUCTS,2010,73(5):806-810
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