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学科主题: Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy
题名: Polyhydroxy Steroids and Saponins from China Sea Starfish Asterina pectinifera and Their Biological Activities
作者: Peng, Y ; Zheng, JX ; Huang, RM ; Wang, YF ; Xu, TH ; Zhou, XF ; Liu, QY ; Zeng, FL ; Ju, HQ ; Yang, XW ; Liu, YH
通讯作者: yonghongliu@scsio.ac.cn
关键词: Asterina pectinifera ; starfish ; polyhydroxy sterol ester ; antiviral ; cytotoxicity
刊名: CHEMICAL & PHARMACEUTICAL BULLETIN
发表日期: 2010
卷: 58, 期:6, 页:856-858
收录类别: sci
部门归属: [Peng, Yan; Huang, Riming; Zhou, Xuefeng; Yang, Xianwen; Liu, Yonghong] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Peng, Yan; Zheng, Jianxian] S China Univ Technol, Coll Light Ind & Food Sci, Guangzhou 510641, Guangdong, Peoples R China; [Peng, Yan] Maoming Univ, Coll Chem & Life Sci, Maoming 525000, Peoples R China; [Wang, Yifei; Liu, Qiuying; Zeng, Fanli; Ju, Huaiqiang] Jinan Univ, Guangzhou Jinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China; [Xu, Tunhai] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
项目归属: LMB
摘要: A new polyhydroxy sterol ester, (25S)-5 alpha-cholestane-3 beta,6 alpha,7 alpha,8,15 beta,16 beta-hexahydroxyl-26-O-14'Z-eicosenoate (1), together with seven known steroid derivatives (2-8), were isolated from the EtOH extract of the whole body of China Sea starfish Asterina pectinifera. The structure of 1 was determined by using extensive spectra analysis (IR, 1D and 2D NMR, and MS), chemical degradation, and comparison with the known compound (25S)-5 alpha-cholestane-3 beta 6 alpha,7 alpha,8,15 alpha,16 beta,26-heptol (2). All the isolates were evaluated for their antiviral activity against herpes simplex virus type 1 (HSV-1) and their cytotoxicity against human liver carcinoma HepG2 cell line in vitro. Compounds 3-6, and 8 exhibited antiviral activity against HSV-1 virus with the minimal inhibitory concentration (MIC) values of 0.2, 0.05, 0.2, 0.22, and 0.07 mu(M), respectively. While compounds 4 and 5 exhibited cytotoxicity against HepG2 cells with IC50 values of 0.2 and 1.6 mu(M), respectively.
原文出处: 查看原文
WOS记录号: WOS:000278131700015
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/3830
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Peng, Y; Zheng, JX; Huang, RM; Wang, YF; Xu, TH; Zhou, XF; Liu, QY; Zeng, FL; Ju, HQ; Yang, XW; Liu, YH.Polyhydroxy Steroids and Saponins from China Sea Starfish Asterina pectinifera and Their Biological Activities,CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(6):856-858
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文件名: Polyhydroxy Steroids and Saponins from China Sea Starfish Asterina pectinifera and Their Biological Activities .pdf
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