Polyhydroxy Steroids and Saponins from China Sea Starfish Asterina pectinifera and Their Biological Activities
Peng, Y; Zheng, JX; Huang, RM; Wang, YF; Xu, TH; Zhou, XF; Liu, QY; Zeng, FL; Ju, HQ; Yang, XW; Liu, YH; yonghongliu@scsio.ac.cn
2010
发表期刊CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN0009-2363
卷号58期号:6页码:856-858
摘要A new polyhydroxy sterol ester, (25S)-5 alpha-cholestane-3 beta,6 alpha,7 alpha,8,15 beta,16 beta-hexahydroxyl-26-O-14'Z-eicosenoate (1), together with seven known steroid derivatives (2-8), were isolated from the EtOH extract of the whole body of China Sea starfish Asterina pectinifera. The structure of 1 was determined by using extensive spectra analysis (IR, 1D and 2D NMR, and MS), chemical degradation, and comparison with the known compound (25S)-5 alpha-cholestane-3 beta 6 alpha,7 alpha,8,15 alpha,16 beta,26-heptol (2). All the isolates were evaluated for their antiviral activity against herpes simplex virus type 1 (HSV-1) and their cytotoxicity against human liver carcinoma HepG2 cell line in vitro. Compounds 3-6, and 8 exhibited antiviral activity against HSV-1 virus with the minimal inhibitory concentration (MIC) values of 0.2, 0.05, 0.2, 0.22, and 0.07 mu(M), respectively. While compounds 4 and 5 exhibited cytotoxicity against HepG2 cells with IC50 values of 0.2 and 1.6 mu(M), respectively.
部门归属[Peng, Yan; Huang, Riming; Zhou, Xuefeng; Yang, Xianwen; Liu, Yonghong] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Peng, Yan; Zheng, Jianxian] S China Univ Technol, Coll Light Ind & Food Sci, Guangzhou 510641, Guangdong, Peoples R China; [Peng, Yan] Maoming Univ, Coll Chem & Life Sci, Maoming 525000, Peoples R China; [Wang, Yifei; Liu, Qiuying; Zeng, Fanli; Ju, Huaiqiang] Jinan Univ, Guangzhou Jinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China; [Xu, Tunhai] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
关键词Asterina Pectinifera Starfish Polyhydroxy Sterol Ester Antiviral Cytotoxicity
学科领域Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
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收录类别sci
资助项目LMB
WOS记录号WOS:000278131700015
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/3830
专题中科院海洋生物资源可持续利用重点实验室
通讯作者yonghongliu@scsio.ac.cn
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GB/T 7714
Peng, Y,Zheng, JX,Huang, RM,et al. Polyhydroxy Steroids and Saponins from China Sea Starfish Asterina pectinifera and Their Biological Activities[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(6):856-858.
APA Peng, Y.,Zheng, JX.,Huang, RM.,Wang, YF.,Xu, TH.,...&yonghongliu@scsio.ac.cn.(2010).Polyhydroxy Steroids and Saponins from China Sea Starfish Asterina pectinifera and Their Biological Activities.CHEMICAL & PHARMACEUTICAL BULLETIN,58(6),856-858.
MLA Peng, Y,et al."Polyhydroxy Steroids and Saponins from China Sea Starfish Asterina pectinifera and Their Biological Activities".CHEMICAL & PHARMACEUTICAL BULLETIN 58.6(2010):856-858.
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