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学科主题: Chemistry, Organic
题名: Abiesatrines A-J: anti-inflammatory and antitumor triterpenoids from Abies georgei Orr
作者: Yang, XW ; Li, SM ; Wu, L ; Li, YL ; Feng, L ; Shen, YH ; Tian, JM ; Tang, J ; Wang, N ; Liu, YH ; Zhang, WD
通讯作者: wdzhangy@hotmail.com
刊名: ORGANIC & BIOMOLECULAR CHEMISTRY
发表日期: 2010
卷: 8, 期:11, 页:2609-2616
收录类别: sci
部门归属: [Yang, Xian-Wen; Wu, Liang; Li, Yong-Li; Feng, Lin; Shen, Yun-Heng; Tian, Jun-Mian; Tang, Jian; Zhang, Wei-Dong] Mil Med Coll 2, Dept Nat Prod Chem, Sch Pharm, Shanghai 200433, Peoples R China; [Yang, Xian-Wen; Li, Su-Mei; Liu, Yonghong] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Wang, Ning] Luxembourg Publ Res Ctr Hlth CRP SANTE, L-1526 Luxembourg, Luxembourg
项目归属: LMB
摘要: A novel spiro-lanostane (abiesatrine A, 1) was isolated from the aerial parts of Abies georgei together with 9 new (abiesatrines B-J, 2-10) and 10 known triterpenes (11-20). The new structures were established by the extensive analysis of their spectroscopic data. The configuration of 1, featuring a unique spirolactone formed by C-13 and C-23 via oxygen-bridge, was confirmed by X-ray crystallography, and its biopathway was tentatively proposed. Among these isolates, compound 16 showed the strongest inhibitory activity against LPS-induced NO production in RAW264.7 macrophages (IC50 = 8.9 mg mL(-1)). While compounds 1 and 20 exhibited potent anti-proliferative effects on QGY-7703 cells with IC50 values of 9.3 and 7.6 mg mL(-1), respectively. Preliminary structure-activity relationship (SAR) investigations defined structural feature of the 24Z-olefinic bond key to the lanostane and cycloartane pharmacophore.
原文出处: 查看原文
WOS记录号: WOS:000277879700019
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/3834
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Yang, XW; Li, SM; Wu, L; Li, YL; Feng, L; Shen, YH; Tian, JM; Tang, J; Wang, N; Liu, YH; Zhang, WD.Abiesatrines A-J: anti-inflammatory and antitumor triterpenoids from Abies georgei Orr,ORGANIC & BIOMOLECULAR CHEMISTRY,2010,8(11):2609-2616
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