Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro
Duan, YQ; Zhang, HH; Xu, FF; Xie, BJ; Yang, XW; Wang, Y; Yan, YS; dyq101@ujs.edu.cn
2010
发表期刊FOOD CHEMISTRY
ISSN0308-8146
卷号122期号:1页码:84-91
摘要Significant growth inhibition effects of procyanidins from lotus (Nelumbo nucifera Gaertn.) seedpod (LSPCs) on mouse melanoma B16 were found both in vivo and in vitro. In vivo treatment with LSPCs inhibited tumour growth in C57BL/6 J mice by 55.3% in terms of average tumour weight. LSPCs can significantly (P < 0.05) decrease lipid peroxidation (LPO) levels and increase the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in liver tissue. In vitro assay of anti-cancer activities suggested that LSPCs (25-100 mu g/ml) possessed cytotoxicities against mouse melanoma B16 in a dose-dependent mode. Furthermore, LSPCs had significant (P<0.05) stimulatory effects on mouse splenocyte proliferation. The prevention of tumour growth was exerted through diverse mechanisms, including cell-cycle arrest, induction of tumour cell death by apoptosis and increase of Ca2+ ions, together with stimulation of antioxidant enzyme activities and immunomodulatory activities. (C) 2010 Elsevier Ltd. All rights reserved.
部门归属[Duan, Yuqing; Zhang, Haihui; Xu, Feifei; Wang, Yong; Yan, Yongsheng] Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China; [Xie, Bijun] Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China; [Yang, Xianwen] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
关键词Lotus Seedpod Procyanidin Melanoma Anti-cancer Activity Apoptosis Immunomodulatory Activity
学科领域Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
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收录类别sci
资助项目LMB
WOS记录号WOS:000277702200013
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被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/3838
专题中科院海洋生物资源可持续利用重点实验室
通讯作者dyq101@ujs.edu.cn
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Duan, YQ,Zhang, HH,Xu, FF,et al. Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro[J]. FOOD CHEMISTRY,2010,122(1):84-91.
APA Duan, YQ.,Zhang, HH.,Xu, FF.,Xie, BJ.,Yang, XW.,...&dyq101@ujs.edu.cn.(2010).Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro.FOOD CHEMISTRY,122(1),84-91.
MLA Duan, YQ,et al."Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro".FOOD CHEMISTRY 122.1(2010):84-91.
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