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学科主题: Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
题名: Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro
作者: Duan, YQ ; Zhang, HH ; Xu, FF ; Xie, BJ ; Yang, XW ; Wang, Y ; Yan, YS
通讯作者: dyq101@ujs.edu.cn
关键词: Lotus seedpod ; Procyanidin ; Melanoma ; Anti-cancer activity ; Apoptosis ; Immunomodulatory activity
刊名: FOOD CHEMISTRY
发表日期: 2010
卷: 122, 期:1, 页:84-91
收录类别: sci
部门归属: [Duan, Yuqing; Zhang, Haihui; Xu, Feifei; Wang, Yong; Yan, Yongsheng] Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China; [Xie, Bijun] Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China; [Yang, Xianwen] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
项目归属: LMB
摘要: Significant growth inhibition effects of procyanidins from lotus (Nelumbo nucifera Gaertn.) seedpod (LSPCs) on mouse melanoma B16 were found both in vivo and in vitro. In vivo treatment with LSPCs inhibited tumour growth in C57BL/6 J mice by 55.3% in terms of average tumour weight. LSPCs can significantly (P < 0.05) decrease lipid peroxidation (LPO) levels and increase the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in liver tissue. In vitro assay of anti-cancer activities suggested that LSPCs (25-100 mu g/ml) possessed cytotoxicities against mouse melanoma B16 in a dose-dependent mode. Furthermore, LSPCs had significant (P<0.05) stimulatory effects on mouse splenocyte proliferation. The prevention of tumour growth was exerted through diverse mechanisms, including cell-cycle arrest, induction of tumour cell death by apoptosis and increase of Ca2+ ions, together with stimulation of antioxidant enzyme activities and immunomodulatory activities. (C) 2010 Elsevier Ltd. All rights reserved.
原文出处: 查看原文
WOS记录号: WOS:000277702200013
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/3838
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Duan, YQ; Zhang, HH; Xu, FF; Xie, BJ; Yang, XW; Wang, Y; Yan, YS.Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro,FOOD CHEMISTRY,2010,122(1):84-91
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文件名: Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro .pdf
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