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学科主题: Chemistry, Medicinal
题名: Polyketides from Marine Dinoflagellates of the Genus Prorocentrum, Biosynthetic Origin and Bioactivity of Their Okadaic Acid Analogues
作者: Hu, WM ; Xu, J ; Sinkkonen, J ; Wu, J
通讯作者: wwujun2003@yahoo.com
关键词: Dinoflagellate ; Prorocentrum ; polyketide ; okadaic acid ; biosynthetic origin ; inhibition to PP1 and PP2A ; pharmacophore
刊名: MINI-REVIEWS IN MEDICINAL CHEMISTRY
发表日期: 2010
卷: 10, 期:1, 页:51-61
收录类别: sci
部门归属: [Hu, Weimin; Wu, Jun] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Xu, Jing] Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China; [Sinkkonen, Jari] Univ Turku, Dept Chem, Lab Organ Chem & Chem Biol, Turku 20014, Finland
项目归属: LMB
摘要: Marine dinoflagellates of the genus Prorocentrum are famous for the production of okadaic acid (OA) and its analogues. This review covers first the source, chemistry and bioactivity of polyketides from Prorocentrum species. Then recent advances in the studies of biosynthetic origin of OA and its analogues are included. Moreover, the pharmacophore for the selective inhibition of OA to protein phosphatases types 1 (PP1) and 2A (PP2A) is highlighted.
原文出处: 查看原文
WOS记录号: WOS:000277156100006
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/3844
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Hu, WM; Xu, J; Sinkkonen, J; Wu, J.Polyketides from Marine Dinoflagellates of the Genus Prorocentrum, Biosynthetic Origin and Bioactivity of Their Okadaic Acid Analogues,MINI-REVIEWS IN MEDICINAL CHEMISTRY,2010,10(1):51-61
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