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学科主题: Chemistry, Multidisciplinary
题名: New Steroids and a New Alkaloid from the Gorgonian Isis minorbrachyblasta: Structures, Cytotoxicity, and Antilarval Activity
作者: Qi, SH ; Miao, L ; Gao, CH ; Xu, Y ; Zhang, S ; Qian, PY
通讯作者: shuhuaqi2001@yahoo.com
刊名: HELVETICA CHIMICA ACTA
发表日期: 2010
卷: 93, 期:3, 页:511-516
收录类别: sci
部门归属: [Qi, Shu-Hua; Gao, Cheng-Hai; Zhang, Si] Chinese Acad Sci, S China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Miao, Li; Xu, Ying; Qian, Pei-Yuan] Hong Kong Univ Sci & Technol, Dept Biol, CML Clearwater Bay, Hong Kong, Hong Kong, Peoples R China
项目归属: LMB
摘要: Two new polyoxygenated steroids, (1 alpha,3 beta,7 alpha,11 alpha,12 beta)-gorgost-5-ene-1,3,7,11,12-pentol 12-acetate (1) and 11-O-acetyl-22-epihippuristanol (2), and a new alkaloid. 2,3,5,6,11,11b-hexahydro-2-hydroxy-1H-indolizine[8,7-b]indole-2-carboxylic acid (3), together with three known compounds. 22-epihippuristanol (4), hippuristanol (5), and tryptamine (6), were isolated from the EtOH/CH2Cl2 extracts of the South China Sea gorgonian Isis minorbruchyblasta. The structures of the new compounds were determined by spectroscopic methods. Compound 1 showed weak cytotoxicity against A549, HONE1. and He La cancer cell lines and strong anti larval activity towards Bugula neritina larvae with an EC50 value of 5.8 mu g/ml. Compound 5 showed moderate cytotoxicity against A549. HONE1, and He La cell lines, and the epimer mixture 4/5 (weight ratio 3 :2) exhibited potent cytotoxicity against A549 and HONE1 cell lines with IC50 values of 4.2 and 4.8 mu g/ml, which indicated that epimers 4 and 5 might have a synergistic effect on their cytotoxicity against A549 and HONE1 cell lines.
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WOS记录号: WOS:000276061600015
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/3866
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Qi, SH; Miao, L; Gao, CH; Xu, Y; Zhang, S; Qian, PY.New Steroids and a New Alkaloid from the Gorgonian Isis minorbrachyblasta: Structures, Cytotoxicity, and Antilarval Activity,HELVETICA CHIMICA ACTA,2010,93(3):511-516
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