Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr
Yang, XW; Feng, L; Li, SM; Liu, XH; Li, YL; Wu, L; Shen, YH; Tian, JM; Zhang, X; Liu, XR; Wang, N; Liu, YH; Zhang, WD; wdzhangy@hotmail.com
2010
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY
ISSN0968-0896
卷号18期号:2页码:744-754
摘要Twenty-five new (abiesadines A-Y, 1-25) and 29 known (26-54) diterpenes were isolated from the aerial parts of Abies georgei. Abiesadine A ( 1) is a novel 8,14-seco-abietane, while abiesadine B ( 2) is a novel 9,10-seco-abietane. The structures of the new compounds were established on the basis of spectroscopic data analysis. Manool ( 52) showed the strongest effect against LPS-induced NO production in RAW264.7 macrophages with the IC50 value of 11.0 mu g/mL. In another anti-inflammatory assay against TNF alpha-triggered NF-kappa B activity, (12R, 13R)-8,12-epoxy-14-labden-13-ol ( 54) exhibited the strongest effect (IC50 = 8.7 mu g/mL). For antitumor assays, pomiferin A (26) and 8,11,13-abietatriene-7 alpha, 18-diol (29) both showed the most significant activity against LOVO cells (IC50 = 9.2 mu g/mL). While 7-oxocallitrisic acid ( 46) exhibited significant cytotoxicity against QGY-7703 tumor cells (IC50 = 10.2 mu g/mL). Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
部门归属[Yang, Xian-Wen; Feng, Lin; Liu, Xiao-Hua; Li, Yong-Li; Wu, Liang; Shen, Yun-Heng; Tian, Jun-Mian; Zhang, Xi; Liu, Xin-Ru; Zhang, Wei-Dong] Mil Med Coll 2, Sch Pharm, Dept Nat Prod Chem, Shanghai 200433, Peoples R China; [Yang, Xian-Wen; Li, Su-Mei; Liu, Yonghong] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Wang, Ning] Luxembourg Publ Res Ctr Hlth CRP SANTE, L-1526 Luxembourg, Luxembourg
关键词Abies Georgei Orr Pinaceae Diterpenes Abiesadines A-y Nitric Oxide (No) Raw264.7 Macrophages
学科领域Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
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收录类别sci
资助项目LMB
WOS记录号WOS:000273613500027
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被引频次:61[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/3914
专题中科院海洋生物资源可持续利用重点实验室
通讯作者wdzhangy@hotmail.com
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Yang, XW,Feng, L,Li, SM,et al. Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(2):744-754.
APA Yang, XW.,Feng, L.,Li, SM.,Liu, XH.,Li, YL.,...&wdzhangy@hotmail.com.(2010).Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr.BIOORGANIC & MEDICINAL CHEMISTRY,18(2),744-754.
MLA Yang, XW,et al."Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr".BIOORGANIC & MEDICINAL CHEMISTRY 18.2(2010):744-754.
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