Microbial biotransformation of water-insoluble herbimycin A to 11-hydroxy-(11-demethoxy)-herbimycin C by Eupenicillium sp SD017
Xie, LW; Wang, GH; Zhang, H; Ouyang, YC; Sun, W; Li, X; xiecsu@126.com
2010
发表期刊JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
ISSN1381-1177
卷号62期号:1页码:76-80
摘要Herbimycin A, a typically water-insoluble anti-tumor drug and an analog of geldanamycin, was transformed by fungus Eupenicillium sp. SD017. The water solubility and anti-tumor activity of converted products were evaluated after separation, purification, and structure elucidation. The results showed that herbimycin A can be converted into herbimycin C 1 and 11-hydroxy-(11-demethoxy)-herbimycin C 2 with water solubility increased. The latter is a novel compound, and its IC50 to A549, MCF-7, Ehrlich and HeLa cells is 152.9, 0.46, 10.7 and 109.3 mu g/ml, respectively, which are nearly in the range of those between herbimycin A and herbimycin C. It is suggested that an O-demethylase or/and methyltransferase may play an important role on biotransformation in this case. This study will firstly serve as a fundamental methodology for further structural alteration and functional improvement of the water-insoluble anti-tumor drugs using microbial resources. (C) 2009 Elsevier B.V. All rights reserved.
部门归属[Xie, Lianwu] Cent S Univ Forestry & Technol, Sch Sci, Changsha 410004, Hunan, Peoples R China; [Xie, Lianwu; Wang, Guanghua; Ouyang, Yongchang; Sun, Wei; Li, Xiang] Chinese Acad Sci, LMB, LMM GD, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Zhang, Hua] N China Pharmaceut Grp Corp, New Drug Res & Dev Ctr, Natl Microbial Med Engn & Res Ctr, Shijiazhuang 050015, Peoples R China
关键词Herbimycin a Biotransformation Water-insoluble Anti-tumor Drug O-demethylase
学科领域Biochemistry & Molecular Biology ; Chemistry, Physical
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收录类别sci
资助项目LMB
WOS记录号WOS:000272316800012
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/3918
专题中科院海洋生物资源可持续利用重点实验室
通讯作者xiecsu@126.com
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Xie, LW,Wang, GH,Zhang, H,et al. Microbial biotransformation of water-insoluble herbimycin A to 11-hydroxy-(11-demethoxy)-herbimycin C by Eupenicillium sp SD017[J]. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,2010,62(1):76-80.
APA Xie, LW.,Wang, GH.,Zhang, H.,Ouyang, YC.,Sun, W.,...&xiecsu@126.com.(2010).Microbial biotransformation of water-insoluble herbimycin A to 11-hydroxy-(11-demethoxy)-herbimycin C by Eupenicillium sp SD017.JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,62(1),76-80.
MLA Xie, LW,et al."Microbial biotransformation of water-insoluble herbimycin A to 11-hydroxy-(11-demethoxy)-herbimycin C by Eupenicillium sp SD017".JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 62.1(2010):76-80.
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