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学科主题: Environmental Sciences; Marine & Freshwater Biology
题名: Relationship between structures of substituted indolic compounds and their degradation by marine anaerobic microorganisms
作者: Gu, JD ; Fan, YZ ; Shi, HC
关键词: anaerobic degradation ; indole ; metabolic pathway ; methanogenic condition ; substitution ; sulfate-reducing condition
刊名: MARINE POLLUTION BULLETIN
发表日期: 2002
卷: 45, 期:40555, 页:379-384
收录类别: sci
部门归属: Univ Hong Kong, Dept Ecol & Biodivers, Lab Environm Toxicol, Hong Kong, Hong Kong, Peoples R China; Chinese Acad Sci, S China Sea Inst Oceanog, Guangzhou 510301, Peoples R China; Univ Hong Kong, Swire Inst Marine Sci, Shek O, Hong Kong, Peoples R China; Tsing Hua Univ, State Key Joint Lab Environm Simulat & Pollut Con, ESPC, Dept Environm Engn, Beijing 100084, Peoples R China
项目归属: 海洋地质
摘要: Degradation of selected indolic compounds including indole, 1-methylindole, 2-methylindole, and 3-methylindole was assessed under methanogenic and sulfate-reducing conditions using the serum-bottle anaerobic technique and marine sediment from Victoria Harbour, Hong Kong as an inoculum. Our results showed that indole degradation was achieved in 28 days by a methanogenic consortium and 35 days by a sulfate-reducing consortium. During degradation under both conditions, two intermediates were isolated, purified and identified as oxindole and isatin (indole-2,3-dione) suggesting that both methanogenic and sulfate-reducing bacteria use an identical degradation pathway. Degradation processes followed two steps of oxidation accomplished by hydroxylation and then dehydrogenation at 2- and then 3-position sequentially prior to the cleavage of the pyrrole ring between 2- and 3-positions. However, none of 1-methylindole or 2-methylindole was degraded under any conditions. 3-Methylindole (3-methyl-1H-indole, skatole) was transformed under methanogenic conditions and mineralized only under sulfate-reducing conditions. It is clear that methyl substitution on 1- or 2-position inhibits the initial attack by hydroxylation enzymes making them more persistent in the environment and posing longer toxic impact. (C) 2002 Elsevier Science Ltd. All rights reserved.
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WOS记录号: WOS:000178336300049
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/4708
Appears in Collections:中科院边缘海地质重点实验室_期刊论文

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Gu, JD; Fan, YZ; Shi, HC.Relationship between structures of substituted indolic compounds and their degradation by marine anaerobic microorganisms,MARINE POLLUTION BULLETIN,2002,45(40555):379-384
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