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学科主题: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
题名: Dimeric Proanthocyanidins from the Roots of Ephedra sinica
作者: Tao, HM ; Wang, LS ; Cui, ZC ; Zhao, DQ ; Liu, YH
通讯作者: yonghongliu@scsio.ac.cn
关键词: Ephedra sinica Stapf ; Ephedraceae ; proanthocyanidins ; ephedrannin B ; mahuannin E ; cytotoxicity
刊名: PLANTA MEDICA
发表日期: 2008
卷: 74, 期:15, 页:1823-1825
收录类别: sci
部门归属: [Tao, Huaming; Liu, Yonghong] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Tao, Huaming; Cui, Zhanchen] Jilin Univ, Coll Chem, Changchun 130023, Peoples R China; [Wang, Lishu; Zhao, Daqing] Changchun Univ Chinese Med, Coll Pharm, Changchun, Peoples R China; [Wang, Lishu] Jilin Prov Acad Chinese Med Sci, Changchun, Peoples R China
项目归属: LMB
摘要: Two new dimeric proanthocyanidins, ephedrannin B (2) and mahuannin E (4), along with two known congeners, ephedrannin A (1) and mahuannin D (3), were isolated from the roots of Ephedra sinica Stapf. Based on NMR, MS, and CD analysis, the structures of the new Compounds were deduced to be 5,7,4'-trihydroxyflavan-[4(alpha)-> 8,2(alpha)-> O -> 7]-kaempferol (2) and 5,7,4'-trihydroxyflavan-[4(beta)-> 8,2(beta)-> O -> 7]-epi-afzelechin (4). The compounds 1-4 were evaluated for cytotoxicity against three tumor cell lines (SGC-7901, HepG2, and HeLa), and 2 was found to be significantly active.
原文出处: 查看原文
WOS记录号: WOS:000262107800012
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/4936
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Tao, HM; Wang, LS; Cui, ZC; Zhao, DQ; Liu, YH.Dimeric Proanthocyanidins from the Roots of Ephedra sinica,PLANTA MEDICA,2008,74(15):1823-1825
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