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学科主题: Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy
题名: Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats
作者: Wang, LS ; Li, W ; Liu, YH
通讯作者: yonghongliu@scsio.ac.cn
刊名: PHARMAZIE
发表日期: 2008
卷: 63, 期:8, 页:606-610
收录类别: sci
部门归属: [Wang, Lishu] Changchun Univ Chinese Med, Coll Pharm, Changchun, Peoples R China; [Wang, Lishu; Li, We] Acad Tradit Chinese Med & Chinese Mat Med Jilin P, Changchun, Peoples R China; [Wang, Lishu; Liu, Yonghong] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou, Guangdong, Peoples R China
项目归属: LMB
摘要: Total alkaloids (VTA) and veratramine of Veratrum nigrum L. were tested for hypotensive effect using spontaneously hypertensive rats (SHR). Acute toxicities were also evaluated. There was a dose-dependent reduction in blood pressure and heart rate after a single ingestion (1.0 to 4.0 mg/kg, intragastric administration) of VTA. A single oral ingestion (0.56 to 2.24 mg/kg) of veratramine, the major component of VTA, dose-dependently decreased blood pressure and heart rate, suggesting that veratramine was involved in the hypotensive effect of VTA in SHR. The hypotensive effects of VTA and veratramine are directly positively correlated with the dosage. Side effects were not obvious.
原文出处: 查看原文
WOS记录号: WOS:000258591300011
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/4964
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Wang, LS; Li, W; Liu, YH.Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats,PHARMAZIE,2008,63(8):606-610
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