中国科学院南海海洋研究所机构知识库
Advanced  
SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室  > 期刊论文
学科主题: Physiology
题名: L-malate reverses oxidative stress and antioxidative defenses in liver and heart of aged rats
作者: Wu, JL ; Wu, QP ; Yang, XF ; Wei, MK ; Zhang, JM ; Huang, Q ; Zhou, XY
通讯作者: wuqp@gdas.ac.cn
关键词: antioxidative defense system ; glutathione peroxidase ; L-malate ; mitochondria ; reactive oxygen species
刊名: PHYSIOLOGICAL RESEARCH
发表日期: 2008
卷: 57, 期:2, 页:261-268
收录类别: sci
部门归属: [Wu, J. -L.; Wu, Q. -P.; Wei, M. -K.; Zhang, J. -M.; Zhou, X. -Y.] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China; [Wu, J. -L.] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China; [Yang, X. -F.; Huang, Q.] Ctr Dis Control & Prevent Guangdong Prov, Dept Toxicol, Guangzhou, Guangdong, Peoples R China; [Wu, J. -L.] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
项目归属: LMB
摘要: The intracellular levels of antioxidant and free radical scavenging enzymes are gradually altered during the aging process. An age-dependent increase of oxidative stress occurring throughout the lifetime is hypothesized to be the major cause of aging. The current study examined the effects of L-malate on oxidative stress and antioxidative defenses in the liver and heart of aged rats. Sprague-Dawley male rats were randomly divided into four groups, each group consisting of 6 animals. Group Ia and Group IIa were young and aged control rats. Group Ib and Group IIb were young and aged rats treated with L-malate (210 mg/kg body weight per day). L-malate was orally administrated via intragastric canula for 30 days, then the rats were sacrificed and the liver and heart were removed to determine the oxidant production, lipid peroxidation and antioxidative defenses of young and aged rats. Dietary L-malate reduced the accumulation of reactive oxygen species (ROS) and significantly decreased the level of lipid peroxidation in the liver and heart of the aged rats. Accordingly, L-malate was found to enhance the antioxidative defense system with an increased activity of antioxidant enzymes, such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) and increased glutathione (GSH) levels in the liver of aged rats, a phenomenon not observed in the heart of aged rats. Our data indicate that oxidative stress was reversed and the antioxidative defense system was strengthened by dietary supplementation with L-malate.
WOS记录号: WOS:000257270700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/4974
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
L-Malate Reverses Oxidative Stress and Antioxidative Defenses in.pdf(322KB)----开放获取--View Download

Recommended Citation:
Wu, JL; Wu, QP; Yang, XF; Wei, MK; Zhang, JM; Huang, Q; Zhou, XY.L-malate reverses oxidative stress and antioxidative defenses in liver and heart of aged rats,PHYSIOLOGICAL RESEARCH,2008,57(2):261-268
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wu, JL]'s Articles
[Wu, QP]'s Articles
[Yang, XF]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wu, JL]‘s Articles
[Wu, QP]‘s Articles
[Yang, XF]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: L-Malate Reverses Oxidative Stress and Antioxidative Defenses in.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院南海海洋研究所 - Feedback
Powered by CSpace