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学科主题: Pharmacology & Pharmacy
题名: Anti-inflammatory and anti-tumour effects of Abies georgei extracts
作者: Yang, XW ; Zeng, HW ; Liu, XH ; Li, SM ; Xu, W ; Shen, YH ; Zhang, C ; Zhang, WD
通讯作者: wdzhangy@hotmail.com
刊名: JOURNAL OF PHARMACY AND PHARMACOLOGY
发表日期: 2008
卷: 60, 期:7, 页:937-941
收录类别: sci
部门归属: [Yang, Xian-Wen; Zeng, Hua-Wu; Liu, Xiao-Hua; Shen, Yun-Heng; Zhang, Chuan; Zhang, Wei-Dong] Mil Med Coll 2, Sch Pharm, Dept Nat Prod Chem, Shanghai 200433, Peoples R China; [Yang, Xian-Wen] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Peoples R China; [Li, Su-Mei] Chinese Acad Sci, Kunming Inst Bot, Dept Ethnobot, Kunming 650204, Peoples R China
项目归属: LMB
摘要: Chloroform (AGC), ethyl acetate (AGE) and n-butanol (AGB) extracts of Abies georgei were investigated for anti-tumour and anti-inflammatory activities in-vitro and in-vivo. AGC exhibited potent antiproliferative effects against A549, LOVO, QGY-7703 and 6T-CEM tumour cells, with EC50 values of 77.5, 7.8, 11.1 and 32.8 mu gmL(-1), respectively. It also inhibited the growth of 5180 sarcoma implanted into mice; tumour growth inhibition ratios were 46.7, 53.1 and 31.0% of controls at doses of 100, 200 and 400 mg kg(-1), respectively. AGE showed significant anti-inflammatory activities in the carrageenin-induced acute pedal oedema model in rats and dimethylbenzene-induced ear oedema in mice at doses of 140 mg kg(-1) and 200 mgkg(-1) p.o., respectively. Primary mechanism studies in-vitro showed that AGE inhibited platelet aggregation induced in rabbits by arachidonic acid (AA), with an IC50 of 14.4 mu gmL(-1). Its effect on AA metabolism was also studied in mouse peritoneal macrophages stimulated by A23187. Formation of prostaglandin E-2, leukotriene B-4 and 5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-HETE) was significantly inhibited in a concentration-dependent manner. In addition, AGE inhibited lipopolysaccharide-induced nitric oxide production in RAW246.7 macrophages and nuclear factor kappa B activation induced in 293 cells by tumour necrosis factor alpha.
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WOS记录号: WOS:000257093800017
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/4978
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Yang, XW; Zeng, HW; Liu, XH; Li, SM; Xu, W; Shen, YH; Zhang, C; Zhang, WD.Anti-inflammatory and anti-tumour effects of Abies georgei extracts,JOURNAL OF PHARMACY AND PHARMACOLOGY,2008,60(7):937-941
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