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学科主题: Fisheries; Marine & Freshwater Biology
题名: Tissue distribution and elimination of florfenicol in tilapia (Oreochromis niloticus x O-caureus) after a single oral administration in freshwater and seawater at 28 degrees C
作者: Feng, JB ; Jia, XP ; Li, LD
通讯作者: fengjb0618@126.com
关键词: tilapia ; florfenicol ; distribution ; elimination
刊名: AQUACULTURE
发表日期: 2008
卷: 276, 期:40547, 页:29-35
收录类别: sci
部门归属: [Feng, Jing-Bin] Chinese Acad Sci, Key Lab Appl Marine Biol Guangdong Province, Guangzhou 510301, Guangdong, Peoples R China; [Jia, Xiao-Ping; Li, Liu-Dong] Chinese Acad Fishery Sci, Key Lab Marine Fishery Ecol Environm & Pollut Mon, S China Fisheries Inst, Guangzhou, Guangdong, Peoples R China; [Feng, Jing-Bin] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
项目归属: LMB
摘要: Tissue distribution and elimination of florfenicol in seawater-acclimated tilapia were compared with those in freshwater tilapia at 28 degrees C after they were given a single oral dose of 10 mg/kg body weight (b.w.). In most sampling time points, the concentrations of florfenicol in the tissues (muscle, liver, kidney, gill and bile) in freshwater tilapia were higher than those in seawater tilapia. In the major elimination phase the elimination half-lives (T-1/2 beta) in all the tissues (except for bile) of freshwater tilapia were longer than those in seawater tilapia. These findings indicated that the distribution level of florfenicol in freshwater tilapia was higher than that in seawater tilapia and the elimination of florfenicol in seawater tilapia was more rapid than that in freshwater tilapia. The main excretion pathway (gill excretion) of the drug in seawater-acclimated tilapia was different from that (bile excretion) in freshwater tilapia, which should be responsible for the considerable difference in pharmacokinetics from freshwater tilapia. (c) 2008 Elsevier B.V. All rights reserved.
原文出处: 查看原文
WOS记录号: WOS:000255791700005
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/4994
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Feng, JB; Jia, XP; Li, LD.Tissue distribution and elimination of florfenicol in tilapia (Oreochromis niloticus x O-caureus) after a single oral administration in freshwater and seawater at 28 degrees C,AQUACULTURE,2008,276(40547):29-35
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文件名: Tissue distribution and elimination of florfenicol in tilapia (Oreochromis niloticus × O. caureus) after a single oral administration in freshwater and seawater at 28 °C.pdf
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