Tissue distribution and elimination of florfenicol in tilapia (Oreochromis niloticus x O-caureus) after a single oral administration in freshwater and seawater at 28 degrees C
Feng, JB; Jia, XP; Li, LD; fengjb0618@126.com
2008
发表期刊AQUACULTURE
ISSN0044-8486
卷号276期号:40547页码:29-35
摘要Tissue distribution and elimination of florfenicol in seawater-acclimated tilapia were compared with those in freshwater tilapia at 28 degrees C after they were given a single oral dose of 10 mg/kg body weight (b.w.). In most sampling time points, the concentrations of florfenicol in the tissues (muscle, liver, kidney, gill and bile) in freshwater tilapia were higher than those in seawater tilapia. In the major elimination phase the elimination half-lives (T-1/2 beta) in all the tissues (except for bile) of freshwater tilapia were longer than those in seawater tilapia. These findings indicated that the distribution level of florfenicol in freshwater tilapia was higher than that in seawater tilapia and the elimination of florfenicol in seawater tilapia was more rapid than that in freshwater tilapia. The main excretion pathway (gill excretion) of the drug in seawater-acclimated tilapia was different from that (bile excretion) in freshwater tilapia, which should be responsible for the considerable difference in pharmacokinetics from freshwater tilapia. (c) 2008 Elsevier B.V. All rights reserved.
部门归属[Feng, Jing-Bin] Chinese Acad Sci, Key Lab Appl Marine Biol Guangdong Province, Guangzhou 510301, Guangdong, Peoples R China; [Jia, Xiao-Ping; Li, Liu-Dong] Chinese Acad Fishery Sci, Key Lab Marine Fishery Ecol Environm & Pollut Mon, S China Fisheries Inst, Guangzhou, Guangdong, Peoples R China; [Feng, Jing-Bin] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
关键词Tilapia Florfenicol Distribution Elimination
学科领域Fisheries ; Marine & Freshwater Biology
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收录类别sci
资助项目LMB
WOS记录号WOS:000255791700005
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/4994
专题中科院海洋生物资源可持续利用重点实验室
通讯作者fengjb0618@126.com
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GB/T 7714
Feng, JB,Jia, XP,Li, LD,et al. Tissue distribution and elimination of florfenicol in tilapia (Oreochromis niloticus x O-caureus) after a single oral administration in freshwater and seawater at 28 degrees C[J]. AQUACULTURE,2008,276(40547):29-35.
APA Feng, JB,Jia, XP,Li, LD,&fengjb0618@126.com.(2008).Tissue distribution and elimination of florfenicol in tilapia (Oreochromis niloticus x O-caureus) after a single oral administration in freshwater and seawater at 28 degrees C.AQUACULTURE,276(40547),29-35.
MLA Feng, JB,et al."Tissue distribution and elimination of florfenicol in tilapia (Oreochromis niloticus x O-caureus) after a single oral administration in freshwater and seawater at 28 degrees C".AQUACULTURE 276.40547(2008):29-35.
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