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Chemical Constituents of Dracocephalum forrestii
Li, SM; Yang, XW; Li, YL; Shen, YH; Feng, L; Wang, YH; Zeng, HW; Liu, XH; Zhang, CS; Long, CL; Zhang, WD;;
Source PublicationPLANTA MEDICA
AbstractA systematic phytochemical examination of the whole plant Dracocephalum forrestii led to the isolation of 4 new and 65 known chemical constituents. By detailed 1D and 2D NMR spectroscopic analyses, the new compounds were identified as 4-hydroxy-3-methoxyphenylethanol 8-O-[(6-O-syringoyl)-beta-D-glucopyranoside] (1), 3,4,5-trimethoxyphenylethanol beta-D-glucopyranoside (2), 4-O-[beta-D-glucopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl]phenylethylcinnamamide (3), and 9 ''-O-n-butyl lithospermate (4). The new isolates were evaluated for inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages. Compound 2 revealed a moderate effect without any cytotoxicity under the assayed concentrations.
Department[Li, Su-Mei; Wang, Yue-Hu; Long, Chun-Lin] Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China; [Yang, Xian-Wen; Li, Yong-Li; Shen, Yun-Heng; Feng, Lin; Zeng, Hua-Wu; Liu, Xiao-Hua; Zhang, Wei-Dong] Mil Med Coll 2, Dept Nat Prod Chem, Sch Pharm, Shanghai 200433, Peoples R China; [Li, Su-Mei; Yang, Xian-Wen; Zhang, Chang-Sheng] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China
KeywordDracocephalum Forrestii Lamiaceae Phenylethanoids Lignans Raw 264.7 Macrophages No
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
Indexed Bysci
Funding ProjectLMB
WOS IDWOS:000273178400007
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Recommended Citation
GB/T 7714
Li, SM,Yang, XW,Li, YL,et al. Chemical Constituents of Dracocephalum forrestii[J]. PLANTA MEDICA,2009,75(15):1591-1596.
APA Li, SM.,Yang, XW.,Li, YL.,Shen, YH.,Feng, L.,...& Constituents of Dracocephalum forrestii.PLANTA MEDICA,75(15),1591-1596.
MLA Li, SM,et al."Chemical Constituents of Dracocephalum forrestii".PLANTA MEDICA 75.15(2009):1591-1596.
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