[Li, Su-Mei; Wang, Yue-Hu; Long, Chun-Lin] Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China; [Yang, Xian-Wen; Li, Yong-Li; Shen, Yun-Heng; Feng, Lin; Zeng, Hua-Wu; Liu, Xiao-Hua; Zhang, Wei-Dong] Mil Med Coll 2, Dept Nat Prod Chem, Sch Pharm, Shanghai 200433, Peoples R China; [Li, Su-Mei; Yang, Xian-Wen; Zhang, Chang-Sheng] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China
项目归属:
LMB
摘要:
A systematic phytochemical examination of the whole plant Dracocephalum forrestii led to the isolation of 4 new and 65 known chemical constituents. By detailed 1D and 2D NMR spectroscopic analyses, the new compounds were identified as 4-hydroxy-3-methoxyphenylethanol 8-O-[(6-O-syringoyl)-beta-D-glucopyranoside] (1), 3,4,5-trimethoxyphenylethanol beta-D-glucopyranoside (2), 4-O-[beta-D-glucopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl]phenylethylcinnamamide (3), and 9 ''-O-n-butyl lithospermate (4). The new isolates were evaluated for inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages. Compound 2 revealed a moderate effect without any cytotoxicity under the assayed concentrations.
