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学科主题: Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy
题名: The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats
作者: Wang, LS ; Cheng, DY ; Wang, HS ; Di, L ; Zhou, XF ; Xu, TH ; Yang, XW ; Liu, YH
通讯作者: yonghongliu@scsio.ac.cn
关键词: Saururus chinensis ; Liver fibrosis ; Carbon tetrachloride ; Hepatoprotective ; Antifibrotic effect
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2009
卷: 126, 期:3, 页:487-491
收录类别: sci
部门归属: [Wang, Lishu; Zhou, Xuefeng; Yang, Xianwen; Liu, Yonghong] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Wang, Lishu; Cheng, Dongyan; Wang, Haisheng; Di, Lin] Jilin Prov Acad Chinese Med Sci, Changchun 130021, Peoples R China; [Xu, Tunhai] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
项目归属: LMB
摘要: Ethnopharmacological relevance: Saururus chinensis (Lour.) Bail] (Saururaceae) has been used in Chinese folk medicine for treatment of various diseases, such as edema,jaundice, gonorrhea, antipyretic, diuretic, and antiinflammatory agents. Aim of the study: Our aim was to evaluate the hepato protective and antifibrotic effects of Saururus chinensis extract (SC-E) in carbon tetrachloride (CCl4) induced liver fibrosis rats. Materials and methods: The SC-E (70 mg/kg) was administrated via gavage once a day starting from the onset Of CCl4 treatment (14 weeks) for subsequent 8 weeks. Evaluated with liver index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), hepatic malondialdehyde (MDA) content, and superoxide dismutase (SOD) activity, total cholesterol (TC), triglyceride (TG), total lipoprotein (TP), albumin (ALB), hydroxyproline (HYP), total antioxidant capacity (T-AOC), laminin (LN), type III collagen terminal peptide (PC-IIINP), and type IV collagen (IV-C), as well as with histopathologic changes of liver. Results: SC-E effectively reduced the elevated levels of liver index, serum ALT, AST, HA, and hepatic MDA contents, enhance the reduced hepatic SOD activity in CCl4-treated rats. The histopathological analysis suggested that SC-E obviously alleviated the degree of liver fibrosis induced by CCl4. Conclusions: Those results suggest SC-E has protective and therapeutic effects on liver fibrosis induced by CCl4. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
原文出处: 查看原文
WOS记录号: WOS:000273157900018
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/5034
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Wang, LS; Cheng, DY; Wang, HS; Di, L; Zhou, XF; Xu, TH; Yang, XW; Liu, YH.The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats,JOURNAL OF ETHNOPHARMACOLOGY,2009,126(3):487-491
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