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学科主题: Chemistry, Medicinal
题名: Exploring and Exploiting Microbial Diversity through Metagenomics for Natural Product Drug Discovery
作者: Li, X ; Guo, J ; Dai, SK ; Ouyang, YC ; Wu, HB ; Sun, W ; Wang, GH
通讯作者: lixiang@scsio.ac.cn
关键词: Metagenomics ; microbial diversity ; drug discovery ; bacterial artificial chromosome
刊名: CURRENT TOPICS IN MEDICINAL CHEMISTRY
发表日期: 2009
卷: 9, 期:16, 页:1525-1535
收录类别: sci
部门归属: [Li, Xiang; Dai, Shikun; Ouyang, Yongchang; Wu, Houbo; Sun, Wei; Wang, Guanghua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Li, Xiang; Dai, Shikun; Ouyang, Yongchang; Wu, Houbo; Sun, Wei; Wang, Guanghua] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Guo, Jun] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China
项目归属: LMB
摘要: Microorganisms of millions species exist in every corner of the Earth, and form a dynamic genetic reservoir that are not clearly revealed and categorized due to barrier in current cultivation technology. Their applications in biomedical and environmental aspects are more than satisfactory. However, the situation has drastically changed during the turn of the century because of the rapid development of phylogenetic studies based on rRNA sequencing independent of standard laboratory cultivation. More recently, high throughput sequencing technology which enables direct sequencing of community DNA for metagenomic analyses are making a direct impact on our understanding of microbial diversity, ecology, and secondary metabolism. In this review, we highlight some recent progress and innovation on metagenomic research with an emphasis on natural product drug discovery. The rapid path of accumulating decoded metagenomics would be an efficient guide on direct access to the genomes of numerous non-culturable microorganisms for their genomic diversity and associated chemical prosperity for potential medicinal applications.
原文出处: 查看原文
WOS记录号: WOS:000272785100003
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/5040
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Li, X; Guo, J; Dai, SK; Ouyang, YC; Wu, HB; Sun, W; Wang, GH.Exploring and Exploiting Microbial Diversity through Metagenomics for Natural Product Drug Discovery,CURRENT TOPICS IN MEDICINAL CHEMISTRY,2009,9(16):1525-1535
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