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学科主题: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
题名: Two New Spirobiflavonoids from Abies chensiensis with Moderate NO Production Inhibitory Activity
作者: Li, YL ; Yang, XW ; Li, SM ; Tang, J ; Tian, JM ; Peng, XY ; Huang, DS ; Zhang, WD
通讯作者: yangxw76@163.com
关键词: Abies chensiensis ; Pinaceae ; spirobiflavonoids ; larixinol ; RAW 264.7 macrophages ; NO
刊名: PLANTA MEDICA
发表日期: 2009
卷: 75, 期:14, 页:1534-1537
收录类别: sci
部门归属: [Yang, Xian-Wen; Li, Su-Mei] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Li, Yong-Li; Yang, Xian-Wen; Tang, Jian; Tian, Jun-Mian; Peng, Xiao-Yang; Huang, Da-Seng; Zhang, Wei-Dong] Mil Med Coll 2, Dept Nat Prod Chem, Sch Pharm, Shanghai, Peoples R China; [Zhang, Wei-Dong] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China
项目归属: LMB
摘要: Phytochemical investigation of the aerial parts of Abies chensiensis afforded two new (compounds 2 and 3) and 27 known compounds, including the related compound larixinol (1). The structures of spirobiflavonoids 1-3 were established using 1D and 2D NMR spectroscopic techniques. In addition, the structure of larixinol (1) was confirmed by X-ray crystallographic analysis. Compounds 1-3 were evaluated for inhibitory activities against LPS-induced NO production in macrophages. Larixinol (1) showed moderate effects, with an IC50 value of 60.0 mu g/mL. In addition, it did not show any cytotoxicity on RAW 264.7 macrophages at 100 mu g/mL.
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WOS记录号: WOS:000272183500014
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/5046
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Li, YL; Yang, XW; Li, SM; Tang, J; Tian, JM; Peng, XY; Huang, DS; Zhang, WD.Two New Spirobiflavonoids from Abies chensiensis with Moderate NO Production Inhibitory Activity,PLANTA MEDICA,2009,75(14):1534-1537
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