Two New Spirobiflavonoids from Abies chensiensis with Moderate NO Production Inhibitory Activity
Li, YL; Yang, XW; Li, SM; Tang, J; Tian, JM; Peng, XY; Huang, DS; Zhang, WD; yangxw76@163.com
2009
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号75期号:14页码:1534-1537
摘要Phytochemical investigation of the aerial parts of Abies chensiensis afforded two new (compounds 2 and 3) and 27 known compounds, including the related compound larixinol (1). The structures of spirobiflavonoids 1-3 were established using 1D and 2D NMR spectroscopic techniques. In addition, the structure of larixinol (1) was confirmed by X-ray crystallographic analysis. Compounds 1-3 were evaluated for inhibitory activities against LPS-induced NO production in macrophages. Larixinol (1) showed moderate effects, with an IC50 value of 60.0 mu g/mL. In addition, it did not show any cytotoxicity on RAW 264.7 macrophages at 100 mu g/mL.
部门归属[Yang, Xian-Wen; Li, Su-Mei] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Li, Yong-Li; Yang, Xian-Wen; Tang, Jian; Tian, Jun-Mian; Peng, Xiao-Yang; Huang, Da-Seng; Zhang, Wei-Dong] Mil Med Coll 2, Dept Nat Prod Chem, Sch Pharm, Shanghai, Peoples R China; [Zhang, Wei-Dong] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China
关键词Abies Chensiensis Pinaceae Spirobiflavonoids Larixinol Raw 264.7 Macrophages No
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
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收录类别sci
资助项目LMB
WOS记录号WOS:000272183500014
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/5046
专题中科院海洋生物资源可持续利用重点实验室
通讯作者yangxw76@163.com
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Li, YL,Yang, XW,Li, SM,et al. Two New Spirobiflavonoids from Abies chensiensis with Moderate NO Production Inhibitory Activity[J]. PLANTA MEDICA,2009,75(14):1534-1537.
APA Li, YL.,Yang, XW.,Li, SM.,Tang, J.,Tian, JM.,...&yangxw76@163.com.(2009).Two New Spirobiflavonoids from Abies chensiensis with Moderate NO Production Inhibitory Activity.PLANTA MEDICA,75(14),1534-1537.
MLA Li, YL,et al."Two New Spirobiflavonoids from Abies chensiensis with Moderate NO Production Inhibitory Activity".PLANTA MEDICA 75.14(2009):1534-1537.
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