Characterization of Singapore grouper iridovirus (SGIV) ORF086R, a putative homolog of ICP18 involved in cell growth control and virus replication
Xia, LQ; Cao, JH; Huang, XH; Qin, QW; lssqinqw@mail.sysu.edu.cn
2009
发表期刊ARCHIVES OF VIROLOGY
ISSN0304-8608
卷号154期号:9页码:1409-1416
摘要Singapore grouper iridovirus (SGIV), as a causative agent of serious systemic disease, causes significant economic losses in grouper aquaculture. In this study, a novel ICP18 homolog encoded by SGIV ORF086R was identified and characterized. Strikingly, ICP18 homologs can be found in all ranaviruses, but not in other sequenced large DNA viruses. SGIV ICP18 is an immediate-early gene and begins to be transcribed as early as 2 h post-infection (p.i.). Western blotting indicated that SGIV ICP18 is translated as early as 6 h p.i. and is a viral non-envelope protein. Subcellular localization analysis revealed that the SGIV ICP18 displays a finely punctate cytoplasmic pattern. Furthermore, overexpression of SGIV ICP18 can promote the growth of grouper embryonic cells (GP) and contribute to SGIV replication. These results should offer important insights into the pathogenesis of ranaviruses.
部门归属[Huang, Xiaohong; Qin, Qiwei] Chinese Acad Sci, Marine Biol Lab, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Xia, Liqun; Cao, Jianhao] Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China
学科领域Virology
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收录类别sci
资助项目LMB
WOS记录号WOS:000269878900004
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/5072
专题中科院海洋生物资源可持续利用重点实验室
通讯作者lssqinqw@mail.sysu.edu.cn
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Xia, LQ,Cao, JH,Huang, XH,et al. Characterization of Singapore grouper iridovirus (SGIV) ORF086R, a putative homolog of ICP18 involved in cell growth control and virus replication[J]. ARCHIVES OF VIROLOGY,2009,154(9):1409-1416.
APA Xia, LQ,Cao, JH,Huang, XH,Qin, QW,&lssqinqw@mail.sysu.edu.cn.(2009).Characterization of Singapore grouper iridovirus (SGIV) ORF086R, a putative homolog of ICP18 involved in cell growth control and virus replication.ARCHIVES OF VIROLOGY,154(9),1409-1416.
MLA Xia, LQ,et al."Characterization of Singapore grouper iridovirus (SGIV) ORF086R, a putative homolog of ICP18 involved in cell growth control and virus replication".ARCHIVES OF VIROLOGY 154.9(2009):1409-1416.
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