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学科主题: Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
题名: Isolation and Difference in Anti-Staphylococcus aureus Bioactivity of Curvularin Derivates from Fungus Eupenicillium sp.
作者: Xie, LW ; Ouyang, YC ; Zou, K ; Wang, GH ; Chen, MJ ; Sun, HM ; Dai, SK ; Li, X
通讯作者: lixiang@scsio.ac.cn
关键词: Curvularin ; alpha beta-Dehydrocurvularin ; Anti-Staphylococcus aureus ; Bioassay-guided isolation
刊名: APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
发表日期: 2009
卷: 159, 期:1, 页:284-293
收录类别: sci
部门归属: [Xie, Lian Wu; Ouyang, Yong Chang; Wang, Guang Hua; Chen, Min Jie; Sun, Hui Min; Dai, Shi Kun; Li, Xiang] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China; [Xie, Lian Wu] Cent S Univ Forestry & Technol, Changsha 410004, Hunan, Peoples R China; [Zou, Kun] China Three Gorges Univ, Med Sci Coll, Yichang 443002, Peoples R China
项目归属: LMB
摘要: With the anti-microbial and anti-tumor composite screening model, bioassay-guided fractionation led to the isolation of two structurally related bioactive compounds, curvularin and alpha beta-dehydrocurvularin, from ethyl acetate extract of Eupenicillium sp. associated with marine sponge Axinella sp. Further study on the structure-activity relationship demonstrated that both compounds exhibited differences in bioactive profiles which are highly associated with their minor structural differences. Both curvularin and alpha beta-dehydrocurvularin have similar level of anti-fungal and anti-tumorous activity, while alpha beta-dehydrocurvularin is active against Staphylococcus aureus with a minimal inhibitory concentration of 375 mu g/ml but curvularin does not. No detectable activity against Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa exists for both compounds. It is suggested that the partial planar backbone structure, due to the conjugation of pi electrons in the presence of a 3,4-double bond and the carbonyl group at position C-2 in alpha beta-dehydrocurvularin, acts as a key factor for the inhibition of S. aureus, a Gram-positive low G + C bacteria that are often the hospital-acquired and/or community-acquired pathogen.
原文出处: 查看原文
WOS记录号: WOS:000269515600026
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/5080
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Xie, LW; Ouyang, YC; Zou, K; Wang, GH; Chen, MJ; Sun, HM; Dai, SK; Li, X.Isolation and Difference in Anti-Staphylococcus aureus Bioactivity of Curvularin Derivates from Fungus Eupenicillium sp.,APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,2009,159(1):284-293
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